1101835-03-3Relevant academic research and scientific papers
β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors
Lin, Li,Shen, Qiang,Chen, Guo-Rong,Xie, Juan
, p. 6348 - 6351 (2008)
β-C-Glycosiduronic acid quinones and β-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl β-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 μM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent.
