1101861-18-0

Basic information

• Product Name: 5-butyl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one
• Synonyms: 5-butyl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one
• CAS NO: 1101861-18-0
• Molecular Weight: 269.346
• Mol File: 1101861-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-butyl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-butyl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one(1101861-18-0)
• EPA Substance Registry System: 5-butyl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one(1101861-18-0)

Safety Data

• Hazardous Substances Data: 1101861-18-0(Hazardous Substances Data)

Upstream product

• 1101861-35-1 ethyl 3-phenyl-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate 
• 109-73-9 N-butylamine 

Relevant articles and documents

Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells

A series of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives were synthesized by the reaction of ethyl 3-aryl-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate and amine in the general heating condition and microwave-assisted condition. The structures of the compounds were determined by IR, 1H NMR and mass spectroscopy, in addition, representative single-crystal structures were characterized by using X-ray diffraction analysis. Preliminary biological evaluation showed that the compounds could inhibit the growth of A549 cells in dosage- and time-dependent manners. The study on structure-activity relationships showed that compounds with 4-chlorophenyl group at pyrazole moiety, such as 5-benzyl-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (3o) had much more inhibitory effects. Compound 3o was the most effective small molecule in inhibiting A549 cell growth and might perform its action through modulating autophagy.