1101861-37-3

Basic information

• Product Name: ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate
• Synonyms: ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate
• CAS NO: 1101861-37-3
• Molecular Weight: 357.634
• Mol File: 1101861-37-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate(1101861-37-3)
• EPA Substance Registry System: ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate(1101861-37-3)

Safety Data

• Hazardous Substances Data: 1101861-37-3(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 938182-43-5 5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1101861-32-8 5-(4-tert-butylbenzyl)-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1101861-34-0 2-(4-chlorophenyl)-5-(3,4-dimethoxyphenethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1101861-29-3 2-(4-chlorophenyl)-5-isopropyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1101861-30-6 5-butyl-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1101861-31-7 5-benzyl-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1101861-33-9 2-(4-chlorophenyl)-5-((6-chloropyridin-3-yl)methyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1310071-12-5 2-(4-chlorophenyl)-5-(2-morpholinoethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1357157-83-5 ethyl 3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate 
• 1357157-60-8 2-(4-fluorobenzylthio)-1-(2-((3-(4-chlorophenyl)1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)-ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1357158-14-5 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate 
• 1357158-09-8 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol 
• 1357158-04-3 tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate 
• 1357157-93-7 (3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methanol 
• 1310071-11-4 2-(4-chlorophenyl)-5-(2-(2-hydroxyethoxy)ethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 

Relevant articles and documents

Design and synthesis of novel pyrazole-based Lp-PLA2 inhibitors

A series of novel pyrazole-based lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors have been designed and synthetized by a variety of acetophenones via a 10-step convergent approach. The synthetic approach is carefully opt

Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells

A series of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives were synthesized by the reaction of ethyl 3-aryl-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate and amine in the general heating condition and microwave-assisted condition. The structures of the compounds were determined by IR, 1H NMR and mass spectroscopy, in addition, representative single-crystal structures were characterized by using X-ray diffraction analysis. Preliminary biological evaluation showed that the compounds could inhibit the growth of A549 cells in dosage- and time-dependent manners. The study on structure-activity relationships showed that compounds with 4-chlorophenyl group at pyrazole moiety, such as 5-benzyl-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (3o) had much more inhibitory effects. Compound 3o was the most effective small molecule in inhibiting A549 cell growth and might perform its action through modulating autophagy.