110191-38-3Relevant academic research and scientific papers
FORMATION OF DERIVATIVES OF β-NAPHTHOLS IN THE REACTION OF HOMOVERATRIC ACID WITH SUBSTITUTED BENZENES IN POLYPHOSPHORIC ESTER; SYNTHESIS OF 6-OXONIABENZANTHRACENE SALTS
Shcherbakova, I. V.,Kuznetsov, E. V.
, p. 149 - 154 (2007/10/02)
A new type of reaction was discovered between homoveratric acid and phenyl ethers in polyphosphoric ester, leading to the formation of derivatives of β-naphthols.The polycyclic analogs of 2-benzopyrylium salts obtained on the basis of the β-naphthols, i.e., 6-oxoniabenzanthracenes, do not enter into recyclization reactions.
Novel 1H-Benzimidazol-4-ols with Potent 5-Lipoxygenase Inhibitory Activity
Buckle, Derek R.,Foster, Keith A.,Taylor, John F.,Tedder, John M.,Thody, Veronica E.,et al.
, p. 2216 - 2221 (2007/10/02)
The synthesis and structure-activity profile of 2-substituted benzimidazol-4-ols as inhibitors of cell-free RBL-1 5-lipoxygenase are discussed, and their potency is compared with that of the standard inhibitors phenidone, AA 861, BW 755C, and nordihydroguaiaretic acid.In contrast to the standard comounds, most did not inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vivo when administered at 200 μM ip to rats subjected to peritoneal anaphylaxis, although five compounds containing a methoxylated benzyl group (compounds 36, 39, 42, and 43) or hydroxylated benzyl group (41) showed similar activity to that of phenidone, nordihydroguaiaretic acid, and AA 861.Of the many compounds tested, two, 5-tert-butyl-7-methyl-2-(trifluoromethyl)-1H-benzimidazol-4-ol (57) and 2-(4-methoxybenzyl)-7-methyl-1H-benzimidazol-4-ol (36), like dexamethasone, inhibited monocyte accumulation in a pleural exudate model of inflammation.Standard lipoxygenase inhibitors such as phenidone, BW 755C, and AA 861 were inactive in this system.
