110201-12-2Relevant academic research and scientific papers
TiCl4-MEDIATED REACTIONS OF SILYL KETENE ACETALS DERIVED FROM N-METHYLEPHEDRINE ESTERS: ASYMMETRIC SYNTHESIS OF β-LACTAMS
Gennari, Cesare,Schimperna, Giuliana,Venturini, Isabella
, p. 4221 - 4232 (2007/10/02)
TiCl4 mediated addition of silyl ketene acetals derived from N-methylephedrine esters to various aldehydes and imines was used as the key-step in the enantio- and diastereo-controlled synthesis of β-lactams.Thus 3,4-trans and cis substituted-2-azetidinone
ASYMMETRIC SYNTHESIS trans-β-LACTAMS THROUGH TiCl4-MEDIATED ADDITION TO IMINES.
Gennari, Cesare,Venturini, Isabella,Gislon, Gabriele,Schimperna, Giuliana
, p. 227 - 230 (2007/10/02)
TiCl4-mediated addition of the chiral silyl ketene acetal (2) to benzylideneaniline proceeds with high stereoselectivity to give, after cyclization, trans-β-lactam (7) in good yield and 95percent e.e.
