110216-83-6

Upstream product

• 110254-69-8 3-Benzyl-4-chlor-1-methyl-2(1H)-chinolon 
• 110229-49-7 4-Benzylamino-3-benzyl-1-methyl-2(1H)-chinolon 

Downstream Products

• 72587-96-3 3-benzyl-4-hydroxy-1-methylquinolin-2(1H)-one 
• 110216-70-1 4-Azido-3-benzyl-1-methyl-2(1H)-chinolon 
• 110229-46-4 3-benzyl-1-methyl-1H-quinolin-2-one 
• 110216-94-9 3-Benzyl-1-methyl-4-tosyloxy-2(1H)-chinolon 

Relevant academic research and scientific papers

Radical Annulation of 2-Cyanoaryl Acrylamides via C=C Double Bond Cleavage: Access to Amino-Substituted 2-Quinolones

A novel annulation of 2-cyanoaryl acrylamides via C=C double bond cleavage has been developed for facile and efficient access to a broad spectrum of functionalized 4-amino-2-quinolones, which are important N-heterocycles. In this transformation, the solvent THF is demonstrated to play a crucial role, and the addition of alkyl radicals to nitrile, 1,5-hydride shift, and cleavage of the C-C bond are involved in the mechanism.

Methods for the Synthesis of 4-Azido-2(1H)-quinolones

4-Hydroxy-2-quinolones 1 are generally found to be converted to the 4-azidocompounds 3 via the 4-chloroquinolones 2, the 4-tosyloxyquinolones 6, or the 4-aminoquinolones 4, respectively.Choice of the reaction conditions and yields depend on the substituen