110217-06-6

Upstream product

• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 17572-85-9 C₁₂H₁₈O₄ 
• 5259-72-3 cyclo-octa-1,5-diene 
• 17572-85-9 rac-2-endo,6-endo-diacetoxy-cis-bicyclo<3.3.0>octane 

Downstream Products

• 389599-94-4 (3aS,6R,6aR)-3,6-Dimethyl-4,5,6,6a-tetrahydro-3aH-pentalen-1-one 

Relevant academic research and scientific papers

Synthetic studies towards novel terpenic natural products kelsoene and poduran: Construction of the complete 4-5-5-fused tricarbocyclic core

A common synthetic approach to the recently reported sesquiterpene kelsoene 1 and the tetraterpene poduran 5, bearing a novel tricyclo[6.2.0.02,6]decane framework, from commercially available 1,5-COD and leading to the first construction of the carbocyclic core present in these natural products is delineated.

Total synthesis of the novel tricyclic sesquiterpene sulcatine G

A synthetic approach to the tricyclic sesquiterpene sulcatine G, 2, bearing a novel tricyclo[6.2.0.02,6]decane framework, from commercially available 1,5-cod and leading to the first total synthesis of the natural product is described.

Total Synthesis of (?)-Pepluanol B: Conformational Control of the Eight-Membered-Ring System

The first total synthesis of the Euphorbia diterpenoid pepluanol B in both racemic and enantioenriched form involves 20 steps from a known bicyclic diol. This synthesis features an unprecedented bromo-epoxidation to control the eight-membered-ring conform

Bicycro [3.3.0] octane -2,6-diyl compd. having, a liquid crystal display element and a liquid crystal composition

A liquid crystal compound having a high stability to heat, light or the like, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy, a suitable

NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

Chiral bicyclo[3.3.0]octa-2,5-dienes as steering ligands in substrate-dependent rhodium-catalyzed 1,4-addition of arylboronic acids to enones

The synthesis of disubstituted chiral diene ligands (3aR,6aR)- and (3aS,6aS)-10 with a pentalene backbone from the corresponding bicyclo[3.3.0]octa1,4-diones 7 is described. The latter were accessible by enzymatic resolution of the racemic diol rac-5 and

Total synthesis and NMR investigations of cylindramide

Cylindramide (1) was built up from three components: a hydroxyornithine derivative 7, a tetrazolylsulfone 8, and a substituted pentalene subunit 9. Derivative 7 was prepared in a six-step reaction sequence involving the Wittig reaction and a Sharpless asy

A simple route to cyclopentane annulation

We have developed a simple method for cyclopentane annulation using inexpensive reagents which is useful for the synthesis of polyquinane systems.

Synthesis of (R,R) and (S,S) bicyclo[3.3.0]octane-2,6-dione interactions between non-conjugated chromophores

Optically pure bicylo[3.3.0]octane-2,6-dione is easily obtained with a yield of 4 % for each enantiomer from 1,5-cyclooctadiene in 5 steps, by resolution of the intermediate diol with menthyloxyacetic acid. Its CD is 60 % larger than twice the CD of a corresponding monoketone indicating interactions between non-conjugated chromophores.