1102229-83-3

Basic information

• Product Name: 2-(4-(trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde
• Synonyms: 2-(4-(trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde
• CAS NO: 1102229-83-3
• Molecular Formula: C₁₂H₇F₃N₂O
• Molecular Weight: 252
• Mol File: 1102229-83-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 252.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• PKA: -1.23±0.22(Predicted)
• CAS DataBase Reference: 2-(4-(trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde(1102229-83-3)
• EPA Substance Registry System: 2-(4-(trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde(1102229-83-3)

Safety Data

• Hazardous Substances Data: 1102229-83-3(Hazardous Substances Data)

Upstream product

• 89793-12-4 ethyl 2-chloropyrimidine-5-carboxylate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 304693-60-5 (2-(4-(trifluoromethyl)phenyl)pyrimidine-5-yl)methanol 
• 90905-31-0 2-(methylsulfanyl)pyrimidine-5-carbaldehyde 
• 38980-96-0 4-(trifluoromethyl)benzimidamide hydrochloride 
• 455-18-5 4-CF₃C₆H₄CN 

Downstream Products

• 1383801-33-9 (+/-)-cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanol 

Relevant articles and documents

Carboxylic acid derivatives and preparation method and use in medicines thereof

The invention relates to carboxylic acid derivatives and a preparation method and use in medicines thereof. Specifically, the invention relates to carboxylic acid derivatives as shown in the general formula (I), a preparation method and pharmaceutically a

Synthesis of Soai Type 2-Arylpyrimidine-5-carbaldehydes through Desulfurative Cross-Coupling with Arylboronic Acids

A two-step synthesis of 2-arylpyrimidine-5-carbaldehydes, which are of relevance as substrates for Soai's asymmetric autocatalysis, was realized by exploiting a hidden threefold symmetry in the target core structure. Condensation of Arnold's C 3-symmetric vinamidinium cation with S-methylisothiouronium sulfate provides 2-methylsulfanyl-pyrimidine-5-carbaldehyde; introduction of aryl groups at C-2 of the latter was accomplished by a Liebeskind-Srogl palladium-catalyzed desulfurative (de-methylsulfanylative) coupling with aryl boronic acids to obtain the target compounds 1 (14 examples, 60-95 % yield). 2-Arylpyrimidine-5-carbaldehydes, which are of relevance as substrates in Soai's asymmetric autocatalysis, are prepared through Liebeskind-Srogl coupling of aryl boronic acids with 2-methylthiopyrimidine-5-carbaldehyde; the latter is obtained in a hydrolytic condensation of two symmetric amidinium salts.

Pyrimidinone compounds

Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.