110236-57-2

Upstream product

• 110236-56-1 methyl N-benzyloxycarbonyl-2-deoxy-3,6-di-O-benzylglucopyranoside 
• 256348-52-4 2,4,6-tri-O-acetyl-3-O-benzyl-L-idopyranosyl trichloroacetimidate 
• 4704-15-8 ((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester 
• 60076-41-7 methyl 4,6-O-benzylidene-2-(benzyloxycarbonyl)-amino-2-deoxy-α-D-glucopyranoside 
• 87907-34-4 ((2S,4aR,6S,7R,8R,8aS)-8-Benzyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-carbamic acid benzyl ester 
• 100-39-0 benzyl bromide 
• 501-53-1 benzyl chloroformate 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 103703-02-2 Acetic acid (2S,3R,4S,5R,6S)-5-acetoxy-2-acetoxymethyl-4-benzyloxy-6-bromo-tetrahydro-pyran-3-yl ester 
• 60076-41-7 methyl 4,6-O-benzylidene-2-(benzyloxycarbonyl)amino-2-deoxy-α-D-glucopyranoside 
• 87907-34-4 methyl 3-O-benzyl-4,6-O-benzylidene-2-(benzyloxycarbonyl)amino-2-deoxy-α-D-glucopyranoside 

Downstream Products

• 110236-58-3 Methyl-3,6-di-O-benzyl-4-O-(3-O-benzyl-α-L-idopyranosyl)-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 110236-61-8 Methyl-4-O-(2-O-acetyl-3-O-benzyl-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 110236-59-4 Methyl-3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 110255-42-0 (2R,3S,4S,5R,6R)-5-Acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-3-hydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 110236-60-7 Acetic acid (4aS,6S,7R,8S,8aR)-8-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 256348-58-0 5-acetoxy-3-(6-acetoxymethyl-3-azido-4-benzyloxy-5-methoxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-(4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 112622-75-0 Methyl-O-(6-O-acetyl-2-azido-3,4-di-O-benzyl-2-desoxy-α-D-glucopyranosyl)-(1->4)-O-(2-O-acetyl-3,6-di-O-benzyl-α-L-idopyranosyl)-(1->4)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-80-7 Methyl-O-<6-O-acetyl-3,4-di-O-benzyl-2-desoxy-2-(trifluoracetylamino)-α-D-glucopyranosyl>-(1->4)-O-(2-O-acetyl-3,6-di-O-benzyl-α-L-idopyranosyl)-(1->4)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-65-8 Methyl-3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-O-benzyliden-α-L-idopyranosyl)-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-68-1 Methyl-4-O-(2-O-acetyl-3,6-di-O-benzyl-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-66-9 Acetic acid (4aS,6S,7R,8S,8aR)-8-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 112622-81-8 Methyl-O-<2-(acetylamino)-3,4-di-O-benzyl-2-desoxy-α-D-glucopyranosyl>-(1->4)-O-(3,6-di-O-benzyl-α-L-idopyranosyl)-(1->4)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-78-3 C₇₃H₈₂N₂O₁₈ 
• 112622-76-1 Methyl-O-(2-azido-3,4-di-O-benzyl-2-desoxy-α-D-glucopyranosyl)-(1->4)-O-(3,6-di-O-benzyl-α-L-idopyranosyl)-(1->4)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 

Relevant academic research and scientific papers

Synthesis of heparin partial structures and their binding activities to platelets

A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [3H]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-D-glucopyranosyl)- (1→4)-O-(2-O-sulfo-α-L-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets.

SYNTHESIS OF AN ANTITHROMBIN BINDING HEPARIN-LIKE PENTASACCHARIDE LACKING 6-O SULPHATE AT ITS REDUCING END.

The synthesis of a pentasaccharide of the structure of the antithrombin (AT-III) binding sequence, but lacking the 6-O sulphate group at the reducing end, is described and its α-Xa activity determined.