110247-85-3

Upstream product

• 134-84-9 4-Methylbenzophenone 
• 100-52-7 benzaldehyde 
• 7664-93-9 sulfuric acid 

Downstream Products

• 50353-99-6 1,2-diphenyl-2-p-tolylethanone 
• 41993-27-5 2,2-diphenyl-1-p-tolylethanone 
• 125847-08-7 1-(4-methylphenyl)-1,2,2-triphenylethanol 
• 111438-18-7 diphenyl-p-tolyl-acetaldehyde 

Relevant academic research and scientific papers

C,O-dilithiated diarylmethanols: Easy and improved preparation by naphthalene-catalysed lithiation of diaryl ketones and reactivity toward electrophiles

The lithiation of different diaryl ketones 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in tetradrofuran at -30°C leads to the formation of the corresponding dianions of the type I, with Met=Li, which react with several electrophiles (E+=MeI, EtBr, Pr(i)CHO, PhCHO, cyclohexanone, MeCN) to give, after hydrolysis, the expected substituted diarylmethanols 2.

Reductive coupling between aromatic aldehydes and ketones or imines by copper catalysis

The copper-catalyzed reductive coupling of two different carbonyl compounds has been achieved. The reaction of aromatic aldehydes and arylketones with a silylboronate in the presence of a catalytic amount of a CuCl-N-heterocyclic carbene (NHC) complex and a stoichiometric amount of alkoxide base yielded cross-coupled 1,2-diol derivatives. A reaction pathway is proposed that involves the catalytic formation of a nucleophilic α-silyloxybenzylcopper(I) species from the aromatic aldehyde and its subsequent coupling with the arylketone. This process was amenable to asymmetric catalysis. This copper catalyst system also enabled the reductive coupling between aromatic aldehydes and imines.