110258-92-9Relevant academic research and scientific papers
Alternative synthesis and the determination of absolute configuration of docetaxel, an anticancer drug
Sekhar,Vishweshwar, Peddy,Acharyulu, Palle V. R.,Anjaneyulu, Yerramilli
, p. 3482 - 3492 (2012)
A simple, efficient, and alternative synthetic route for docetaxel with better control on the protection-deprotection sequence has been developed. The process is easily scalable and commercially viable, and critical impurities can be controlled efficiently. For the first time, absolute configuration of docetaxel was determined unambiguously by single-crystal X-ray diffraction.
CHEMICAL STUDIES OF 10-DEACETYL BACCATIN III. HEMISYNTHESIS OF TAXOL DERIVATIVES.
Gueritte-Voegelein, F.,Senilh, V.,David, B.,Guenard, B.,Potier, P.
, p. 4451 - 4460 (2007/10/02)
The chemical reactivities of 10-deacetyl baccatin III and of baccatin III, two natural products extracted from Taxus baccata L., were studied with aim of synthesizing taxol analogues having a modified side-chain at C-13, thereby restoring good binding to tubulin.
