110271-93-7Relevant academic research and scientific papers
Synthesis of benzyl hydrazine derivatives: Via amination of benzylic C(sp3)-H bonds with dialkyl azodicarboxylates
Samzadeh-Kermani
, p. 4766 - 4772 (2018)
A novel synthesis of benzyl hydrazines through oxidative amination of benzylic C-H bonds has been developed. The resulting aminated products are accessed directly from the reaction of alkylarenes with dialkyl/diphenyl azodicarboxylates using Cu2O/Phen as the catalytic system. The reaction proceeded smoothly and a decent range of N-substituted hydrazides was synthesized in acceptable to good yields. Both primary and secondary sp3 C-H sources afford only monoamination products.
Visible light catalyzed saturated carbon-hydrogen bond direct oxidizing method
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Paragraph 0040-0044, (2017/08/29)
The invention provides a visible light catalyzed saturated carbon-hydrogen bond direct oxidizing method which is characterized by comprising the following step of performing a reaction on an organic compound and an oxidizing reagent in the presence of a cerium complex in a visible light irradiating condition to oxidize a saturated carbon-hydrogen bond of the organic compound to obtain an oxidized product. According to the method provided by the invention, the reaction is only performed at room temperature, so that the catalytic efficiency is high; energy required by an activating reaction is provided by means of visible light, so that the method is a more mild and green activating mode; and meanwhile, the used catalyst is low in cost, and the used oxidizing reagent is more stable in property, the industrial utilization cost is low, and the practicality of a catalytic system is high; meanwhile, pollution caused by heavy transition metals, peroxides and the like can be avoided.
Reactions of α-Hydroxy Carbonyl Compounds with Azodicarboxylates and Triphenylphosphine: Synthesis of α-N-Hydroxy Amino Acid Derivatives
Kolasa, Teodozyj,Miller, Marvin J.
, p. 4978 - 4984 (2007/10/02)
Reaction of aliphatic α-hydroxy esters with azodicarboxylates and triphenylphosphine in the presence of either CbzNHOCH2Ph or trOCNHOCH2Ph provides a direct route to protected α-N-hydroxy amino acids.Similar reactions with aromatic α-hydroxy carbonyl compounds and derivatives result in predominate oxidation to the corresponding α-oxo carbonyl derivatives.
