110283-41-5

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 627-18-9 1-bromo-3-propanol 
• 76-26-6 camphor-10-sulfonic acid 

Downstream Products

• 101620-20-6 1-(3-benzhydryloxy-propyl)-piperazine 
• 110283-47-1 1-(3-Benzhydryloxy-propyl)-piperidine-3-carboxylic acid ethyl ester 
• 35474-44-3 (3-benzhydryloxy-propyl)-dimethyl-amine 
• 129084-26-0 1-[3-(diphenylmethoxy)propyl]-3-(3-methoxyphenyl) pyrrolidine chlorohydrate 
• 110283-71-1 1-<3-(diphenylmethoxy)propyl>-3-piperidinecarboxylic acid 
• 61945-66-2 (3-benzhydryloxy-propyl)-trimethyl-ammonium; iodide 

Relevant academic research and scientific papers

Practical preparation of diphenylmethyl ethers from 2-diphenylmethoxypyridine using catalytic iron(III) chloride

A novel facile synthetic method for producing diphenylmethyl (DPM) ethers from 2-diphenylmethoxypyridine was developed. A variety of DPM ethers was successfully achieved with high yield via treatment of alcohols with 2-diphenylmethoxypyridine in the presence of catalytic FeCl3. The procedure is a practical and efficient synthetic procedure to protect various alcohols, and it can be applied to prepare bioactive compounds.

CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS

A compound of the formula: wherein R 1 and R 2 each represents hydrogen, lower alkyl which may be substituted or acyl; R 3, R 4 and R 5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R 4 and R 5 taken together represent a 5-or 6-membered carbocyclic group; R 6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5-to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH 2, COCH 2, OCH 2, SCH 2, NHCH 2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.

Structure-Activity Studies on Benzhydrol-Containing Nipecotic Acid and Guvacine Derivatives as Potent, Orally-Active Inhibitors of GABA Uptake

The introduction of lipophilic groups onto the ring nitrogen of nipecotic acid and guvacine, two known GABA uptake inhibitors, afforded potent, orally-active anticonvulsant drugs.A series of compounds is reported which explores the structure-activity relationships (SAR) in this series.Among the areas explored: side-chain SAR (aromatic-, heterocyclic-, and tricyclic-containing side chains) and modifications to the tetrahydropyridine ring.The benzhydrol ether-containing side chains afforded the most potent compounds with several exhibiting in vitro IC50 values for GABA uptake of 1 μM (including 5, Table I; 37, 43, Table IV; and 44, Table V).Compound 44 was selected for extensive evaluation and subsequently progressed to Phase 1 clinical trials with severe adverse effects seen after single dose administration to humans.