110284-90-7Relevant academic research and scientific papers
Rate acceleration of nucleophilic substitution of 2-chloro-4,6- dimethoxypyrimidine by sulfinate catalysis
Bessard, Yves,Crettaz, Roger
, p. 4739 - 4745 (2000)
The use of sulfinates greatly enhances the rate of substitution in the reaction of 2-chloro-4,6-dimethoxypyrimidine with alkoxy or aryloxy nucleophiles. Pyrimidinyloxy derivatives as intermediates for potent herbicides have been prepared in good yields fr
Design, synthesis and herbicidal activity of novel cyclic phosphonates with diaryl ethers containing pyrimidine
Zhang, Shasha,Guo, Xinjuan,Zhou, Yuan,Yang, Yalan,Peng, Hao,He, Hongwu
supporting information, p. 1158 - 1163 (2019/07/04)
Thirteen novel cyclic phosphates were rationally designed and synthesized by introducing diary ethers containing pyrimidine. All the target compounds were characterized by 1H, 13C, 31P NMR and HRMS. The test of herbicidal activity indicated that most of the compounds showed good herbicidal activities against Amaranthus retroflexus. The compounds IA-2 (1-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)propyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) and IA-3 ((5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)(phenyl)methyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) exhibited remarkable post-emergency herbicidal activity against the tested monocotyledonous weed at the dosage of 112.5 g ai/ha.
Synthesis and herbicidal activity of novel dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxypyrimidin-2-yloxy) benzoate derivatives
Jin, Chuanfei,He, Hongwu
experimental part, p. 1397 - 1403 (2011/10/04)
A series of dialkoxyphosphoryl aryl methyl 2-(4,6-dimethoxy-pyrimidin-2- yloxy) benzoate derivatives was designed and synthesized. All new compounds were identified by elemental analysis, infrared (IR), 1H-NMR, and mass spectrometry (MS). Their herbicidal
Synthesis and biological evaluation of novel phosphonates derivatives of as potential antitumor agents
Jin, Chuanfei,Liang, Yong-Ju,He, Hongwu,Fu, Liwu
experimental part, p. 2096 - 2103 (2011/12/01)
A series of dialkyl [2-(4,6-dimethoxypyrimidin-2-yloxy)benzamido](aryl) methylphosphonates derivatives were designed and synthesized. All the new compounds were identified by elemental analysis, IR, 1H NMR, 31P NMR, and MS. Their antitumor activity against KB and CNE1 cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further study of structure modification. In particular, the compounds 6i and 6j displayed more potent cytotoxic activities against KB in comparison with 5-FU. Copyright Taylor & Francis Group, LLC.
Process for the preparation of substituted pyrimidines
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, (2008/06/13)
A novel process for the preparation of substituted pyrimidine derivatives of the general formula: STR1 in which a halopyrimidine is reacted in the presence of a sulfinate with a compound selected from the series: STR2 The compounds of the general formula I are precursors of, for example, compounds with herbicidal activity.
Dimethoxypyrimidines as Novel Herbicides. Part 2. Synthesis and Herbicidal Activity of O-Pyrimidinylsalicylates and Analogues
Nezu, Yukio,Miyazaki, Masahiro,Sugiyama, Kazuhiko,Wada, Nobuhide,Kajiwara, Ikuo,Miyazawa, Takeshige
, p. 115 - 124 (2007/10/03)
A new series of the O-pyrimidinylsalicylates was synthesized and their herbicidal activity was examined. Some of these compounds showed very strong herbicidal activity under pre- and post-emergent treatment conditions against various kinds of grass and broadleaf weeds. Among these compounds, O-(4,6-dimethoxypyrimidin-2-yl)salicylic acid and its methyl ester were found to exhibit the highest activity. The herbicidal symptoms observed after the treatments included early cessation of plant growth followed by chlorosis, necrosis and plant death. The symptoms were similar to those caused by sulfonylureas and imidazolinones, which inhibit branched-chain acid biosynthesis.
2-(4',6'-di-substituted pyrimidine-2'-yl)oxy- or thio-benzoic acid
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, (2008/06/13)
As new compounds are provided 2-(4',6'-di-substituted pyrimidine-2'-yl)oxy- or thio-benzoic acid derivatives of the formula STR1 wherein R is hydrogen, hydroxy, alkoxy, alkenyloxy, alkylthio or other substituents, R1 and R2 are each
