110286-57-2Relevant articles and documents
Antibacterial compounds
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Page/Page column 18, (2008/06/13)
Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the
Novel antibacterial class: A series of tetracyclic derivatives
Hinman, Mira M.,Rosenberg, Teresa A.,Balli, Darlene,Black-Schaefer, Candace,Chovan, Linda E.,Kalvin, Douglas,Merta, Philip J.,Nilius, Angela M.,Pratt, Steve D.,Soni, Niru B.,Wagenaar, Frank L.,Weitzberg, Moshe,Wagner, Rolf,Beutel, Bruce A.
, p. 4842 - 4856 (2007/10/03)
We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this paper we
Antibacterial compounds
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Page/Page column 15, (2008/06/13)
Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods
Novel inhibitors of bacterial protein synthesis: Structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants
Clark, Richard F.,Wang, Sanyi,Ma, Zhenkun,Weitzberg, Moshe,Motter, Christopher,Tufano, Michael,Wagner, Rolf,Gu, Yu-Gui,Dandliker, Peter J.,Lerner, Claude G.,Chovan, Linda E.,Cai, Yingna,Black-Schaefer, Candace L.,Lynch, Linda,Kalvin, Douglas,Nilius, Angela M.,Pratt, Steve D.,Soni, Niru,Zhang, Tianyuan,Zhang, Xiaolin,Beutel, Bruce A.
, p. 3299 - 3302 (2007/10/03)
Structure-activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary efforts to optimize protein synthesis inhibitory activity of the series through modification of positions 3 an
Rearrangements encountered in the attempted syntheses of pyridoazepinone carboxylic acids
Sanders, William J.,Zhang, Xiaolin,Wagner, Rolf
, p. 4527 - 4530 (2007/10/03)
(Chemical equation presented) Attempts to synthesize pyridoazepinone carboxylic acids such as 33 by standard methodologies resulted exclusively in unusual and unexpected rearrangement products. Seven-membered ring formation was attempted by ring expansion
Antibacterial compounds
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Page 39, 46, (2010/02/03)
Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.