908339-90-2

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 110286-57-2 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester 

Downstream Products

• 908340-05-6 (3aS)-10-(2,4-dimethoxybenzyl)-7-oxo-2,3,3a,4,7,10-hexahydro-1H-pyrrolo[1',2':4,5][1,4]oxazino[3,2-b][1,8]-naphthyridine-8-carboxylic acid 
• 908340-04-5 1-(2,4-dimethoxybenzyl)-6-fluoro-7-[(S)-2-hydroxymethylpyrrolidin-1-yl]-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Antibacterial compounds

Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the

Novel antibacterial class: A series of tetracyclic derivatives

We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this paper we