110321-22-7Relevant academic research and scientific papers
Characterization and properties of monoammine nitroimidazole complexes of platinum [PtCl2(NH3)(NO2Im)]. Crystal and molecular structure of cis-amminedichloro(1-{(((2-hydroxyethyl)amino)carbonyl)methyl}-2-nitroimidazole) platinum(II)
Rochon, Fernande D.,Kong, Pi-Chang,Melanson, Robert,Skov, Kirsten A.,Farrell, Nicholas
, p. 4531 - 4535 (2008/10/08)
The characterization of monoammine(nitroimidazole)platinum(II) complexes of structure [PtCl2(NH3)(NO2Im)] (NO2Im = 1-{(((2-hydroxyethyl)amino)carbonyl)methyl}-2-nitroimidazole, Etanidazole (I), 1-{2-nitro-1-imidazolyl}-3-methoxy2-propanol, Misonidazole (II), and 1-{2-hydroxyetnyl}-2-methyl-5-nitroimidazole, Metronidazole (III)) is reported. Both cis and trans isomers may be isolated for II and III. The crystal structure of cis-amminedichloro(1-{(((2-hydroxyethyl)amino)carbonyl)methyl}-2-nitroimidazole) platinum(II) has been determined by X-ray diffraction. The crystals are orthorhombic, space group Pnab with cell dimensions a = 14.867 (7) ?, b = 9.915 (5) ?, c = 19.015 (9) ?, and Z = 8. The structure was refined to R = 0.062 and Rw = 0.052. Platinum has the expected square-planar coordination. The Pt-Cl bond trans to the nitroimidazole ligand is shorter (2.269 (3) ?) than normal. The dihedral angle between the platinum plane and the imidazole ring is 111°, while the nitro group makes an angle of 31° with the imidazole ring plane. Electrochemistry and 195Pt NMR data are also reported. The relevance of the chemical properties to their biological properties as radiosensitizers and hypoxic cytotoxins is discussed.
