1103234-57-6

Basic information

• Product Name: N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide
• Synonyms: N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide;N-(3-Amino-2,4-difluorophenyl)propanesulfonamide;N-(3-aMino-2,4-difluorophenyl)
• CAS NO: 1103234-57-6
• Molecular Formula: C₉H₁₂F₂N₂O₂S
• Molecular Weight: 250.2655864
• EINECS: 604-604-1
• Mol File: 1103234-57-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 337.8±52.0 °C(Predicted)
• Appearance: /
• Density: 1.441±0.06 g/cm3(Predicted)
• PKA: 8.08±0.10(Predicted)
• CAS DataBase Reference: N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide(1103234-57-6)
• EPA Substance Registry System: N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide(1103234-57-6)

Safety Data

• Hazardous Substances Data: 1103234-57-6(Hazardous Substances Data)

Usage

General Description

N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide, also known as DF-2593A, is a chemical compound that belongs to the class of sulfonamides. It is an organic molecule containing a sulfonamide group attached to a propane-1-sulfonamide backbone and a 3-amino-2,4-difluorophenyl group. This chemical is used in the pharmaceutical industry as a potential drug candidate for treating various diseases. The compound has attracted attention due to its potential antibacterial and antifungal properties, as well as its potential for treatment against certain cancers. Studies have shown that N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide exhibits promising biological activities, making it a subject of interest for further research and development.

Upstream product

• 535170-20-8 tert-butyl (3-amino-2,6-difluorophenyl)carbamate 
• 535170-17-3 tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate 
• 260552-98-5 2,6-difluoro-3-nitrobenzoic acid chloride 
• 3896-29-5 N-(2,6-difluorophenyl)acetamide 
• 5509-65-9 2,6-difluoroaniline 
• 385-00-2 2,6-difluorobenzoic acid 
• 1186223-50-6 methyl 2,6-difluoro-3-(propylsulfonamido)benzoate 
• 13671-00-6 methyl 2,6-difluorobenzoate 
• 84832-01-9 methyl 2,6-difluoro-3-nitrobenzoate 
• 1186193-95-2 methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate 
• 84832-02-0 methyl 3-amino-2,6-difluorobenzoate 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 
• 1103234-83-8 C₁₄H₂₀F₂N₂O₄S 

Downstream Products

• 1103233-01-7 propane-1-sulfonic acid {2,4-difluoro-3-[(quinolin-3-ylmethyl)amino]phenyl}amide 
• 1103233-00-6 quinoline-3-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269421-68-2 4-chloro-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide 
• 1269420-21-4 4-amino-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269421-77-3 N-(3-amino-2,4-difluorophenyl)pyrrolidine-1-sulfonamide 
• 1269421-78-4 N-(2,6-difluoro-3-(pyrrolidine-1-sulfonamido)phenyl)-4-(2,4-dimethoxybenzylamino)quinazoline-8-carboxamide 
• 1269420-56-5 4-amino-quinazoline-8-carboxylic acid [2,6-difluoro-3-(pyrrolidine-1-sulfonylamino)-phenyl]-amide 
• 1269420-79-2 quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-amide 
• 1269420-95-2 4-amino-6-methyl-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-amide 
• 1269420-96-3 4-(cyclopentylamino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)-6-methylquinazoline-8-carboxamide 
• 1269421-69-3 4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide 
• 1269420-22-5 4-amino-pyrido[4,3-d]pyrimidine-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-amide 
• 1269421-85-3 N-(2,6-difluoro-3-(propylsulfonamido)phenyl)-4-(2,4-dimethoxybenzyl-amino)-6-(3-hydroxyprop-1-ynyl)quinazoline-8-carboxamide 
• 1269420-62-3 4-amino-6-(3-hydroxy-prop-1-ynyl)-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonyl-amino)phenyl]amide 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.

Discovery of a highly specific and potent pan-RAF inhibitor

We describe the structure-based design and synthesis of N-(2,6-difluorophenyl)-3-(9H-purin-6-yl)pyridine-2-amine derivatives as a selective pan-RAF kinase inhibitor. The synthesized compounds showed highly potent and specific inhibition of the BRAFV600E mutant cell line. Among them, N-(3-((3-(9H-purin-6-yl) pyridine-2-yl)amino)-2,4-difluorophenyl)furan-3-sulfonamide (4b) exhibited the most potent inhibitory activities against protein kinase enzymes BRAFV600E, BRAFWT, and CRAF (IC50 of 2, 2, and 1 nM, respectively) and a mutant cell line bearing a BRAFV600E mutation, A375P (GI50 of 7 nM).