N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide

Base Information

• Chemical Name: N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide
• CAS No.: 1103234-57-6
• Molecular Formula: C9H12F2N2O2S
• Molecular Weight: 250.269
• Mol file: 1103234-57-6.mol

Synonyms:N-(3-aMino-2,4-difluorophenyl)propane-1-sulfonaMide;N-(3-Amino-2,4-difluorophenyl)propanesulfonamide

Chemical Property of N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide

Chemical Property:

• Boiling Point: 337.8±52.0 °C(Predicted)
• PKA: 8.08±0.10(Predicted)
• PSA: 80.57000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 3.43370

Purity/Quality:

98%Min ^*data from raw suppliers

N-(3-Amino-2,4-difluorophenyl)propane-1-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide

There total 17 articles about N-（3-amino-2,4-difluorophenyl）propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid (1103234-56-5) → N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide (1103234-57-6)

Guidance literature:

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 20 - 80 ℃; for 5h;

With water; In tetrahydrofuran; at 80 ℃; for 15h;

Reference yield:

C14H20F2N2O4S (1103234-83-8) → N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide (1103234-57-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide (1383745-37-6) → N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide (1103234-57-6)

Guidance literature:

N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide; With hydrogenchloride; In ethanol; water; at 80 ℃; for 2h;

With sodium hydroxide; In water; pH=6;

upstream raw materials:

C₁₄H₂₀F₂N₂O₄S

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid

2,6-difluoro-3-nitrobenzoic acid

methyl 3-amino-2,6-difluorobenzoate

Downstream raw materials:

propane-1-sulfonic acid {2,4-difluoro-3-[(quinolin-3-ylmethyl)amino]phenyl}amide

quinoline-3-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide

4-chloro-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide

4-amino-quinazoline-8-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide