11033-22-0

Usage

Uses

Used in Pharmaceutical Industry:
Coformycin is used as an antiviral agent for its ability to inhibit the replication of certain viruses, such as the influenza virus. It functions by blocking the activity of the viral enzyme neuraminidase, which is essential for the release of new virus particles from infected cells.
Used in Research Applications:
Coformycin is used as a research tool for studying the structure and function of neuraminidase enzymes, as well as the mechanisms of viral replication and pathogenesis. It can also be used to investigate the development of new antiviral drugs and therapies.

InChI:InChI=1/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1

Related news

Regular ArticleHow Important Is theN-3 Sugar Moiety in the Tight-Binding Interaction of coformycin (cas 11033-22-0) with Adenosine Deaminase?☆08/22/2019

Preliminary findings on the possible important role of the N-3 sugar moiety of coformycin in its tight-binding interaction with adenosine deaminase (ADA) are reported. The compound 3-β-D-Ribofuranosyl-5,6,7,8tetrahydro-4H-imidazo[4,5-d][1,3]diazepin-5-one-8-ol (1), its 3-benzyl analogue (6), an...detailed

Isolation of mutant adenosine deaminase by coformycin (cas 11033-22-0) affinity chromatography☆08/18/2019

Adenosine deaminase is a purine salvage enzyme that catalyzes the deamination of adenosine and deoxyadenosine. Deficiency of the enzyme activity is associated with T-cell and B-cell dysfunction. Mutant adenosine deaminase has been isolated from heterozygous and homozygous deficient lymphoblast c...detailed

Relevant academic research and scientific papers

Separation of coformycin and its related nucleosides

A known nucleoside, coformycin and its related substances such as isocoformycin, 2'-deoxycoformycin and formycins present as a mixture of them may be separated from each other when an aqueous solution containing them is chromatographed on a column of a cation-exchanger having partially activated carboxylic groups as the ion-exchange function with using water or a buffer solution as the developing solvent.