110347-82-5

Upstream product

• 4606-07-9 ethyl cyclopropylcarboxylate 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 1363285-94-2 (S)-(1-(3-(4-methylphenyl)-7-(4-fluorophenyl)-2-ethylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol 
• 1363285-88-4 (S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol 
• 1363293-82-6 5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine 
• 1363293-80-4 2-cyclopropyl3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidin-5(4H)-one 
• 1160100-84-4 4-(4-chlorophenyl)-3-cyclopropyl-1H-pyrazol-5-amine 
• 110347-78-9 2,4-diamino-5-(4-chlorophenyl)-6-cyclopropyl-pyrimidine 
• 110892-16-5 (Z)-2-(4-Chloro-phenyl)-3-cyclopropyl-3-methoxy-acrylonitrile 

Relevant academic research and scientific papers

Latent Inhibition of Dihydrofolate Reductase by a Spirocyclopropyl Pteridine

2-Amino-7,8-dihydro-6-hydroxymethyl-7-spirocyclopropylpteridin-4(3H)-one is shown to be the first mechanism-based inhibitor of dihydrofolate reductase whereas 2,4-diamino-5-(4-chlorophenyl)-6-cyclopropyl-pyrimidine is a typical competitive inhibitor.

NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR

Disclosed is a novel compound acting as a cannabinoid receptor 1 inhibitor, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The novel compound or the like is useful for preventing or treating diseases mediated by the cannabinoid receptor-1.

Latent Inhibitors. Part 5. Latent Inhibition of Dihydrofolate Reductase by a Pteridine-spiro-cyclopropane

The design of cyclopropane-containing enzyme activated inhibitors of dihydrofolate reductase is presented.The synthesis of two examples, 2-amino-7,8-dihydro-6-hydroxymethylpteridine-7-spirocyclopropan-4(3H)-one and 2,4-diamino-5-(4-chlorophenyl)-6-cyclopropylpyrimidine, is described.Kinetic studies with dihydrofolate reductase from E. coli are presented to show that the former is a time-dependent inhibitor of the enzyme whereas the latter is a typical competitive inhibitor.The results are interpreted with regard to the active site structure of dihydrofolate reductase.