Journal of the Chemical Society. Chemical communications p. 478 - 480 (1987)
Update date:2022-08-04
Topics:
Haddow, John
Suckling, Colin J.
Wood, Hamish C. S.
2-Amino-7,8-dihydro-6-hydroxymethyl-7-spirocyclopropylpteridin-4(3H)-one is shown to be the first mechanism-based inhibitor of dihydrofolate reductase whereas 2,4-diamino-5-(4-chlorophenyl)-6-cyclopropyl-pyrimidine is a typical competitive inhibitor.
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(1987)
