110352-57-3Relevant academic research and scientific papers
On the conversion of structural analogues of (S)-2-hydroxypropylphosphonic acid to epoxides by the final enzyme of fosfomycin biosynthesis in S. fradiae
Schweifer, Anna,Hammerschmidt, Friedrich
, p. 3056 - 3059 (2008/12/23)
2-Hydroxyethyl- and (S)-2-hydroxybutylphosphonic acid were prepared, starting in the latter case from (S)-2-aminobutyric acid. They were fed to cultures of Streptomyces fradiae producing fosfomycin. Only the latter (150 μg/mL of medium) was converted to the ethyl analogue of fosfomycin, isolated as 2-amino-1-hydroxybutylphosphonic acid (3%) in admixture with 2-amino-1-hydroxypropylphosphonic acid (97%) derived from fosfomycin.
Stereoselective total synthesis of lysocellin, the representative polyether antibiotic of the lysocellin family. Part 1. Synthesis of C1-C9 and C16-C23 subunits
Horita, Kiyoshi,Inoue, Takayuki,Tanaka, Kazuhiro,Yonemitsu, Osamu
, p. 531 - 550 (2007/10/03)
The C1-C9 (4) and C16-C23 subunits (9) of lysocellin (1), a representative polyether antibiotic, were synthesized stereoselectively from D-glucose and D-mannitol. Stereocontrolled hydroboration, Michael reaction, Grignard reaction, etc. were successfully
ENZYME-MEDIATED ASYMMETRIC HYDROLYSIS OF α-BENZYLOXYCARBOXYLIC ESTERS
Kato, Yasuo,Ohta, Hiromichi,Tsuchihashi, Gen-ichi
, p. 1303 - 1306 (2007/10/02)
Incubation of dl-α-benzyloxycarboxylic esters with grown cells of a bacterium, Corynebacterium equi IFO 3730, afforded the chiral esters of high optical purities via asymmetric hydrolysis.This reaction has been revealed to have a wide applicability to alkene- and arylalkene-carboxylic esters.
