1103692-76-7Relevant academic research and scientific papers
Efficient synthesis of 4-halo-2,5-dihydro-1,2-oxaphosphole 2-oxides from 1,2-allenylphosphonates and CuX2 and subsequent suzuki cross-coupling of the C-Cl bonds
Xin, Ning,Ma, Shengming
experimental part, p. 3806 - 3817 (2012/09/22)
A convenient and efficient synthesis of 4-halo-2,5-dihydro-1,2-oxaphosphole 2-oxides through CuX2-mediated direct halocyclization of diethyl 1,2-allenylphosphonates was developed. The yields range from moderate to excellent. The efficiency of axial-to-central chirality transfer has also been studied. Further Suzuki cross-coupling of the resulting vinylic chlorides with dicyclohexyl(2,4,6-trimethoxyphenyl)phosphane (LB-Phos) as the ligand, was established. CuX2-mediated direct halocyclization of diethyl 1,2-allenylphosphonates was developed to afford 4-halo-2,5-dihydro-1,2- oxaphosphole 2-oxides. The efficiency of axial-to-central chirality transfer and subsequent Suzuki cross-coupling of the resultingvinylic chlorides with dicyclohexyl(2,4,6-trimethoxyphenyl)phosphane (LB-Phos) as the ligand were also investigated. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
CuX2-mediated halolactonization reaction of monoesters of 1,2-allenyl phosphonic acids and their suzuki cross-coupling reaction
Yu, Fei,Lian, Xiongdong,Zhao, Jinbo,Yu, Yihua,Shengming, Ma.
supporting information; experimental part, p. 1130 - 1134 (2009/07/04)
CuX2-mediated (X = Cl, Br) halolactonization of monoesters of 1,2-allenyl phosphonic acids is presented.The reaction proceeded smoothly under the mild condition for differently substituted allenic substrates giving the 4-halo-2,5-dihydro[1,2]ox
