110383-07-8Relevant academic research and scientific papers
Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation
Iseki, Kalsuhiko,Kuroki, Yoshichika,Nagai, Takabumi,Kobayashi, Yoshiro
, p. 477 - 480 (2007/10/03)
The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (Ru-BINAP) and Rh-BINAP was carried out with good enantiomeric excess (71-83% ee). Ru-BINAP-catalyzed hydrogenation converted 2-(trifluoromethyl)acrylic acid to the corresponding saturated acid whose esterification and reduction provided optically active 2-(trifluoromethyl)propan-1-ol in 80% ee.
Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation
Iseki, Katsuhiko,Kuroki, Yoshichika,Nagai, Takabumi,Kobayashi, Yoshiro
, p. 5 - 6 (2007/10/02)
The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-BINAP and Rh-BINAP has been carried out with good enantiomeric excess (71percent-83percent ee).Ru-BINAP-catalyzed hydrogenation converted 2-trifluoromethylacrylic acid to the corresponding saturated acid, the esterification and reduction of which gave optically active 2-(trifluoromethyl)propan-1-ol in 80percent ee.
