1103935-84-7Relevant academic research and scientific papers
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters
Keck, Gary E.,Poudel, Yam B.,Welch, Dennie S.,Kraft, Matthew B.,Truong, Anh P.,Stephens, Jeffrey C.,Kedei, Noemi,Lewin, Nancy E.,Blumberg, Peter M.
supporting information; experimental part, p. 593 - 596 (2009/09/27)
(Chemical Equation Presented) A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C30 carbomethoxy group (on the C13 enoate of the B-ring), has been prepared by total synthesis. Bio
MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF
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Page/Page column 64; 70-71; 7/26, (2009/12/02)
Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
