110396-82-2Relevant academic research and scientific papers
Preparation method of O-nitroaryl urea compound
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Paragraph 0034-0053; 0056, (2021/08/11)
The invention discloses a preparation method of an o-nitryl aryl urea compound, and the method comprises the following steps: adding carbodiimide as shown in a formula I and ceric ammonium nitrate as shown in a formula II into an organic solvent for reaction, and performing separating and purifying after the reaction is completed to obtain the o-nitryl aryl urea compound as shown in a formula III, wherein R1 is selected from alkyl, alkoxy, trifluoromethyl, halogen or ester group; R2 is selected from alkyl, alkenyl or alkynyl. Carbodiimide and ceric ammonium nitrate are used as basic raw materials, and different substituted urea nitro compounds are obtained in one step. The reaction raw materials are easy to prepare, and the atom economy is high; reaction conditions are mild, and operability is high; and the substrate universality is high.
PREPARATION AND PROPERTIES OF 3-ALKYL-i-ARYLNITROSOUREAS AND RELATED COMPOUNDS
Tanno, Masayuki,Sueyoshi, Shoko
, p. 1360 - 1371 (2007/10/02)
Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99percent formic acid or with isoamyl nitrite in chloroform.The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1-nitrosoureas were isomerized to the 3-nitroso isomers by acids.The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and their structural features are discussed.It was found that 3-alkyl-1-aryl-1-nitrosoureas decomposed to form alkyl isocyanates and 3-alkyl-1-(2-nitroaryl)ureas in carbon tetrachloride. 1,3-Rearrangement and transnitrosation also took place in this solvent.Keywords - 3-alkyl-1-arylnitrosourea; 3,3-diethyl-1-tolyl-1-nitrosourea; N-nitrosourea; nitrosation; 1,3-rearrangement; isomerization; transnitrosation; nitration
