110397-48-3Relevant academic research and scientific papers
New synthetic technology for the synthesis of hindered α-diazoketones via acyl mesylates
Nicolaou,Baran, Phil S.,Zhong, Yong-Li,Choi, Ha-Soon,Fong, Kin Chiu,He, Yun,Yoon, Won Hyung
, p. 883 - 886 (2008/02/09)
(equation presented) A mild and reliable one-pot protocol for the elaboration of sterically demanding carboxylic acids into α-diazoketones via acyl mesylates has been developed. Aside from delineating the reaction parameters which render this strategy quite general for hindered carboxylic acids, we have directly proven the existence of the fleeting acyl mesylate group as the reactive species in these reactions and shed light onto the differing mechanisms which are operative in the activation of hindered and simple carboxylic acids with methanesulfonyl chloride.
Synthesis of 2-Indanones by Intramolecular Insertion of α-Diazoketones
Nakatani, Kazuhiko
, p. 165 - 166 (2007/10/02)
The reaction of α-diazoketones from phenylacetic acid derivatives affords 2-indanones in good yield.Insertion into the aromatic C-H bond was found to be favored over insertion into an aliphatic one.
