110406-94-5

Basic information

• Product Name: Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide
• Synonyms: Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide;N'-(1-Methylazepan-4-yl)benzohydrazide;1-Benzoyl-2-[(4RS)-1-methylhexahydro-1H-azepin-4-yl]diazane;Methylazepan benzohydrazide;Azelastine EP Impurity B
• CAS NO: 110406-94-5
• Molecular Formula: C14H21N3O
• Molecular Weight: 247.33604
• Mol File: 110406-94-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 345.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.44±0.20(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide(110406-94-5)
• EPA Substance Registry System: Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide(110406-94-5)

Safety Data

• Hazardous Substances Data: 110406-94-5(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 2-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazide is a compound that is chemically derived from benzoic acid and hydrazine. It is commonly used as a corrosion inhibitor and as a preservative in food and beverages. Benzoic acid, 2-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazide has antifungal and antibacterial properties, making it useful in a variety of industrial and consumer products. It may also have potential applications in the pharmaceutical industry due to its biological activity. Overall, Benzoic acid, 2-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazide is a versatile chemical with a range of practical uses across different industries.

Upstream product

• 1859-33-2 1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 79307-93-0 azelastine hydrochloride 
• 58581-89-8 azelastine 

Relevant articles and documents

Preparation method of azelastine hydrochloride

The invention relates to the technical field of synthesis of raw material medicines, and particularly discloses a preparation method of azelastine hydrochloride. The method comprises the following steps: condensing benzoyl hydrazine and 1-methylhexahydroazepine-4-one serving as raw materials, reducing with sodium borohydride, and reacting to obtain a compound 1; preparing a solid intermediate compound 2 from the compound 1 and organic binary weak acid; hydrolyzing the compound 2, and cyclizing with a compound 3 to form a compound 4; and salifying the compound 4 by hydrochloric acid, and separating water by toluene to obtain a compound 5, namely azelastine hydrochloride. The intermediate compound 2 prepared by the invention is a solid, the stability of the intermediate compound 2 is greatly improved compared with that of hydrochloride obtained in other literatures, the intermediate compound 2 is free of hygroscopicity, the purity can reach 99% or above, the quality risk of subsequent bulk drugs can be greatly reduced, and the process production operation space is larger; and the obtained azelastine hydrochloride does not contain water and meets related quality standards, the yield is increased to 80% or above compared with other literatures, and the purity can reach 99% or above.