1104077-12-4Relevant academic research and scientific papers
Condensed isoquinolines 25. Alkylation of 6,11-dihydro-13H-isoquino[3,2-b] quinazolin-13-one
Potikha,Kovtunenko
, p. 1445 - 1454 (2008/09/20)
Interaction of 6,11-dihydro-13H-isoquino[2,3-b]quinazolin-13-one with alkylating agents occurs at two positions depending on their nature and the reaction conditions-at C(6) or N(5). Fusion with methyl tosylate leads to 5-methyl-13-o
Condensed isoquinolines 24. Reaction of 6,11-dihydro-13H-isoquino[3,2-b] quinazolin-13-one with carbonyl compounds
Potikha,Kovtunenko
, p. 1280 - 1289 (2008/09/19)
The reaction of 6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-one with carbonyl compounds occurs at the C(6) and/or N(5) atoms depending on the nature of the reagent and the conditions. Condensation with aldehydes gives 6-arylidene-6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-ones. Acylation using acid anhydrides or acid chlorides gave 5-acyl-, 6-acyl-, and 5,6-diacyl-5,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-ones depending again on the reaction conditions. Acylation using chloroacetyl chloride is accompanied by an intramolecular alkylation to give 7H,8H-2a, 7a-diaza-cyclopenta[f,g] naphthacene-1,7(2H)-dione. Phenyl isocyanate gave the derivative containing a CONHPh group at position 6.
