1104077-74-8Relevant academic research and scientific papers
Modified chelation-controlled reduction of an N -acryloyloxazolidin-2-one
Connolly, Terrence J.,Ding, Zhixian,Gong, Yumin,MacEwan, Michael F.,Szeliga, Jan,Alimardanov, Asaf
body text, p. 1448 - 1452 (2011/09/20)
A key step in the synthesis of an optically active aminoalcohol-containing active pharmaceutical ingredient (API) involved the diasteroselective reduction of a chiral 3-acryloyl-4-benzyloxazolidin-2-one. Preliminary work identified that excellent facial s
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF HETEROCYCLIC SULFONAMIDE COMPOUNDS
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Page/Page column 22-23, (2009/02/11)
Methods for preparing compound of formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Also described are methods for enantioselectively preparing a chiral compou
PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES
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Page/Page column 10; 13-14, (2009/02/11)
A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the fol
Practical enantioselective synthesis of a 3-aryl-3-trifluoromethyl-2- aminopropanol derivative
Alimardanov, Asaf,Nikitenko, Antonia,Connolly, Terrence J.,Feigelson, Gregg,Chan, Anita W.,Ding, Zhixian,Ghosh, Mousumi,Shi, Xinxu,Ren, Jianxin,Hansen, Eric,Farr, Roger,MacEwan, Michael,Tadayon, Sam,Springer, Dane M.,Kreft, Anthony F.,Ho, Douglas M.,Potoski, John R.
experimental part, p. 1161 - 1168 (2010/04/22)
Development of a large-scale enantioselective synthesis of a lead compound containing a 3-aryl-3-trifluoromethyl-2-aminopropanol core is described. A single isomer of 3,3-disubstituted acrylic acid derivative was prepared via Perkin condensation or Horner
