(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one
CAS No.:1104077-74-8
Molecular Formula:C₂₀H₁₆F₅NO₃
Molecular Weight:413.344
Hs Code.:

Synonyms:(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

There total 6 articles about (S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 1104029-21-1
4-(S)-benzyl-3-[3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-but-2-enoyl]oxazolidin-2-one

: 1104077-74-8
(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; magnesium chloride; In 2-methyltetrahydrofuran; at 70 - 75 ℃; under 3863.02 - 4121.6 Torr; diastereoselective reaction; Large scale reaction;
DOI:10.1021/op100074m

Reference yield: 80.0%

: C₁₅H₁₅F₅O₃

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1104077-74-8
(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

Guidance literature:: (S)-4-Benzyl-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexane; at -74 - -64 ℃; for 1.5h;

C₁₅H₁₅F₅O₃; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 17.5h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 5 ℃; Product distribution / selectivity;

Reference yield: 76.0%

: 1104029-21-1
4-(S)-benzyl-3-[3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-but-2-enoyl]oxazolidin-2-one

: 1104077-74-8
(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

: C₁₉H₁₆F₅NO

: C₁₉H₁₇BrF₅NO

Guidance literature:: With palladium 10% on activated carbon; hydrogen; magnesium bromide; In tetrahydrofuran; at 50 ℃; for 4h; under 3604.44 Torr; diastereoselective reaction;
DOI:10.1021/op100074m