1104083-27-3

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-3-methyl-3-hydroxypiperidine is used as a protecting group for amines in the synthesis of various drugs and pharmaceutical intermediates. Its ability to protect amine groups allows for the efficient and selective synthesis of complex molecules, improving the yield and purity of the final products.
Used in Agrochemical Production:
Boc-piperidine is used as a key intermediate in the production of agrochemicals, where its protecting group properties enable the synthesis of active ingredients with desired properties and improved performance.
Used in Dye Synthesis:
1-Boc-3-methyl-3-hydroxypiperidine is used as a building block in the synthesis of dyes, where its versatility in protecting amine groups allows for the development of dyes with specific color properties and improved stability.
Used in Fine Chemicals Production:
Boc-piperidine is utilized in the production of various fine chemicals, where its protecting group properties contribute to the synthesis of high-quality and specialized chemical products for diverse applications.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 473730-88-0 3-methylpiperidin-3-ol 

Relevant academic research and scientific papers

DOPAMINE D2 RECEPTOR LIGANDS

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0- arrestin pathway and/or on the cAMP pathway.

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)

A multidimensional, iterative parallel synthesis effort identified a series of highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration. Of these, ML337 resulted (mGlu3 IC50 = 593 nM, mGlu2 IC50 >30 μM) with B:P ratios of 0.92 (mouse) to 0.3 (rat). DMPK profiling and shallow SAR led to the incorporation of deuterium atoms to address a metabolic soft spot, which subsequently lowered both in vitro and in vivo clearance by >50%.