1104375-65-6Relevant academic research and scientific papers
De novo asymmetric approaches to 2-amino-n-(Benzyloxycarbonyl)-1-(2'fury)ethanol and 2-amino-n-(tert-butoxycarbonyl)-1-(2'furyl)ethanol
Haukaas, Michael H.,Li, Miaosheng,Starosotnikov, Alexey M.,O'Doherty, George A.
experimental part, p. 1549 - 1559 (2009/09/06)
Several methods were investigated for the de novo asymmetric synthesis of 2-amino-N-(benzyloxycarbonyl)-1-(2'-furyl)ethanol and 2-amino-N-(tert-butoxycarbonyl)-1-(2'-furyl)ethanol. A five step procedure was developed for the practical preparation of optically pure 2-amino-N-benzyloxycarbonyl)-1-(2'-furyl)ethanol and a shorter 2-step procedure was developed for 2-amino-N-(tert-butoxycarbonyl)-1-(2'-furyl)ethanol. Both routes used a Noyori reduction to install the asymmetry.
