1104606-44-1

Basic information

• Product Name: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone
• Synonyms: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone;2-Chloro-1-(5-fluoro-2-pyridyl)ethanone;2-chloro-1-(5-fluoro-2-pyridinyl)Ethanone
• CAS NO: 1104606-44-1
• Molecular Formula: C7H5ClFNO
• Molecular Weight: 173.5721032
• Mol File: 1104606-44-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 244.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.337±0.06 g/cm3(Predicted)
• PKA: -0.36±0.10(Predicted)
• CAS DataBase Reference: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(1104606-44-1)
• EPA Substance Registry System: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(1104606-44-1)

Safety Data

• Hazardous Substances Data: 1104606-44-1(Hazardous Substances Data)

Usage

General Description

2-chloro-1-(5-fluoropyridin-2-yl)ethanone is a chemical compound with the molecular formula C7H6ClNOF. It is a chlorinated pyridine derivative with a ketone functional group. 2-chloro-1-(5-fluoropyridin-2-yl)ethanone is commonly used in the pharmaceutical industry as a building block for the synthesis of various organic compounds and drugs. It is also used as an intermediate in the production of agrochemicals, dyes, and other fine chemicals. 2-chloro-1-(5-fluoropyridin-2-yl)ethanone may also have potential applications in medicinal chemistry and drug discovery due to its unique structure and reactivity. However, it is important to handle this chemical with caution and adhere to proper safety measures due to its potential health hazards and reactivity.

Upstream product

• 41404-58-4 2-bromo-5-fluoropyridine 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 

Relevant articles and documents

Discovery of MK-1421, a potent, selective sstr3 antagonist, as a development candidate for type 2 diabetes

The imidazolyl-tetrahydro-β-carboline class of sstr3 antagonists have demonstrated efficacy in a murine model of glucose excursion and may have potential as a treatment for type 2 diabetes. The first candidate in this class caused unacceptable QTc interval prolongation in oral, telemetrized cardiovascular (CV) dogs. Herein, we describe our efforts to identify an acceptable candidate without CV effects. These efforts resulted in the identification of (1R,3R)-3-(4-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl)-1-(1-ethyl-pyrazol-4-yl)-1-(3-methyl-1,3,4-oxadiazol-3H-2-one-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline (17e, MK-1421).

OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.