1104606-44-1

Basic information

• Product Name: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone
• Synonyms: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone;2-Chloro-1-(5-fluoro-2-pyridyl)ethanone;2-chloro-1-(5-fluoro-2-pyridinyl)Ethanone
• CAS NO: 1104606-44-1
• Molecular Formula: C7H5ClFNO
• Molecular Weight: 173.5721032
• Mol File: 1104606-44-1.mol

Chemical Properties

• Boiling Point: 244.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.337±0.06 g/cm3(Predicted)
• PKA: -0.36±0.10(Predicted)
• CAS DataBase Reference: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(1104606-44-1)
• EPA Substance Registry System: 2-chloro-1-(5-fluoropyridin-2-yl)ethanone(1104606-44-1)

Safety Data

• Hazardous Substances Data: 1104606-44-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-1-(5-fluoropyridin-2-yl)ethanone is used as a building block for the synthesis of various organic compounds and drugs, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Production:
2-chloro-1-(5-fluoropyridin-2-yl)ethanone serves as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of various agricultural chemicals that help protect crops and enhance their yield.
Used in Dye Manufacturing:
2-chloro-1-(5-fluoropyridin-2-yl)ethanone is utilized as an intermediate in the manufacturing of dyes, contributing to the creation of a wide range of colorants used in various industries, including textiles, plastics, and printing.
Used in Fine Chemicals Synthesis:
2-chloro-1-(5-fluoropyridin-2-yl)ethanone is also employed in the synthesis of other fine chemicals, which are high-purity, specialty chemicals used in various applications, such as research, pharmaceuticals, and advanced materials.
Used in Medicinal Chemistry and Drug Discovery:
Due to its unique structure and reactivity, 2-chloro-1-(5-fluoropyridin-2-yl)ethanone may have potential applications in medicinal chemistry and drug discovery, where it can be used to explore new chemical entities and develop innovative therapeutic agents.
It is important to handle 2-chloro-1-(5-fluoropyridin-2-yl)ethanone with caution and adhere to proper safety measures due to its potential health hazards and reactivity.

Upstream product

• 41404-58-4 2-bromo-5-fluoropyridine 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 

Relevant articles and documents

Discovery of MK-1421, a potent, selective sstr3 antagonist, as a development candidate for type 2 diabetes

The imidazolyl-tetrahydro-β-carboline class of sstr3 antagonists have demonstrated efficacy in a murine model of glucose excursion and may have potential as a treatment for type 2 diabetes. The first candidate in this class caused unacceptable QTc interval prolongation in oral, telemetrized cardiovascular (CV) dogs. Herein, we describe our efforts to identify an acceptable candidate without CV effects. These efforts resulted in the identification of (1R,3R)-3-(4-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl)-1-(1-ethyl-pyrazol-4-yl)-1-(3-methyl-1,3,4-oxadiazol-3H-2-one-5-yl)-2,3,4,9-tetrahydro-1H-β-carboline (17e, MK-1421).

Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases

The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases.

OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.