67442-07-3Relevant academic research and scientific papers
Substituted Tetraethynylethylene–Tetravinylethylene Hybrids
Connor, Kieran P. E.,Horvath, Kelsey L.,Magann, Nicholas L.,Sherburn, Michael S.,Sowden, Madison J.,Westley, Erin
supporting information, p. 977 - 986 (2022/02/03)
A general synthetic approach to molecular structures that are hybrids of tetraethynylethylene (TEE) and tetravinylethylene (TVE) is reported. The synthesis permits the controlled preparation of many previously inaccessible structures, including examples w
Development of a practical synthesis to PI3K α-selective inhibitor GDC-0326
Koenig, Stefan G.,Green, Keena L.,Müller, Barbara,Sowell, C. Gregory,Askin, David,Gosselin, Francis
, (2020/12/29)
A practical route to PI3K α-selective inhibitor GDC-0326 is reported. The synthesis leverages an existing scheme to a key tetracyclic benzoxazepine intermediate and optimizes it for robustness and scalability, including removing numerous undesired conditions and reagents, as well as eliminating chromatographic purification steps. The process endgame is streamlined to utilize a single-step, stereocontrolled alkylation of the key phenol with a chiral lactamide mesylate, followed by recrystallization of the lactamide ether product, to deliver the desired enantiomer of the active pharmaceutical ingredient (API) GDC-0326.
Concise and Efficient Synthesis of [6]-Paradol
Shi, Xiang,Xia, Tiantian,McKamey, Brooke E.,Wu, Xian,Sun, Yue,Zhou, Weifeng,Zhang, Guangyan
, p. 1360 - 1365 (2021/06/21)
An efficient synthesis of [6]-paradol (1) has been performed in four steps with a 72.0% overall yield. The present method highlights commercially available materials, convenient isolation with multiple crystallization without involving column chromatography, and a high-purity product (more than 99.2%), and it is amenable to large-scale synthesis.
3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF
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Paragraph 0389-0390, (2021/10/14)
The present invention discloses 3 - substituted anilino compounds of formula (I) in which R 1, R 2, R 3, R 4, R 44a, R 44b, A and E are as defined in the description. The present invention further discloses processes for preparing compounds of general formula (I) and using compounds of general formula (I) as crop protection agents for agricultural crops.
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Page, Claire G.,Cooper, Simon J.,Dehovitz, Jacob S.,Oblinsky, Daniel G.,Biegasiewicz, Kyle F.,Antropow, Alyssa H.,Armbrust, Kurt W.,Ellis, J. Michael,Hamann, Lawrence G.,Horn, Evan J.,Oberg, Kevin M.,Scholes, Gregory D.,Hyster, Todd K.
supporting information, p. 97 - 102 (2021/01/12)
Intermolecular C-C bond-forming reactions are underdeveloped transformations in the field of biocatalysis. Here we report a photoenzymatic intermolecular hydroalkylation of olefins catalyzed by flavin-dependent 'ene'-reductases. Radical initiation occurs via photoexcitation of a rare high-order enzyme-templated charge-transfer complex that forms between an alkene, α-chloroamide, and flavin hydroquinone. This unique mechanism ensures that radical formation only occurs when both substrates are present within the protein active site. This active site can control the radical terminating hydrogen atom transfer, enabling the synthesis of enantioenriched γ-stereogenic amides. This work highlights the potential for photoenzymatic catalysis to enable new biocatalytic transformations via previously unknown electron transfer mechanisms.
Paradol synthesis method
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Paragraph 0032; 0038, (2020/04/17)
The invention discloses a complete synthesis method of a natural product paradol, the route being represented as the specification. The method employs feasible raw materials and simple operation, is high in yield and low in cost, is high in final product purity, is controllable in quality, and is suitable for industrial production.
PESTICIDAL MIXTURES COMPRISING A MESOIONIC COMPOUND
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Page/Page column 48; 51; 52, (2020/04/25)
Pesticidal mixtures comprising as active compounds 1) pesticidally active compound A of formula (I) and 2) at least one further compound B selected from compounds B1 to B22 as described in claims and the description.
PYRIMIDINIUM COMPOUNDS AND THEIR MIXTURES FOR COMBATING ANIMAL PESTS
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Paragraph 0386; 0403, (2020/07/31)
The present invention relates to pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof, their mixtures and to compositions comprising such compounds or mixtures. The invention also relates to methods and uses o
METHOD OF CONTROLLING RICE PESTS IN RICE
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Paragraph 0154; 0155, (2020/09/22)
The present invention relates to methods for controlling rice pest invertebrates, which methods comprise applying pyrimidinium compounds of formula (I), the stereoisomers, salts, tautomers and N-oxides thereof, their mixtures and compositions comprising such compounds or mixtures, by seedling box application.
PROCESS FOR PREPARING S-CONTAINING PYRIMIDINIUM COMPOUNDS
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Paragraph 0318-0319, (2020/08/18)
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.
