1104608-06-1

Upstream product

• 108-93-0 cyclohexanol 
• 156-83-2 6-chloro-pyrimidine-2,4-diyldiamine 

Downstream Products

• 1104608-07-2 1-(2-amino-4-cyclohexyloxypteridin-6-yl)-1R,2S-1-hydroxy-2-(methoxymethoxy)propan 
• 1254938-85-6 4-cyclohexyloxy-6-{1-[4-[2-(hydroxyethyl)phenylamino]ethyl]}-7-methylpterin 
• 1254938-84-5 4-cyclohexyloxy-6-[1-(phenylamino)ethyl]-7-methylpterin 
• 1254938-82-3 4-cyclohexyloxy-6-[1-(4-ethylphenylimino)ethyl]-7-methylpterin 
• 1254938-83-4 4-cyclohexyloxy-6-{1-[4-(2-hydroxyethyl)phenylimino]ethyl}-7-methylpterin 
• 1254938-81-2 4-(cyclohexyloxy)-7-methyl-6-[1-(4-methylphenylimino)ethyl]pterin 
• 1254938-80-1 4-(cyclohexyloxy)-7-methyl-6-[1-(phenylimino)ethyl]pterin 
• 1254938-73-2 6-acetyl-4-cyclohexyloxy-7-methylpterin 

Relevant academic research and scientific papers

Preparation method of 2,4,5-triamido-6-cyclohexyl pyrimidine hydrochloride

The invention discloses a preparation method of 2,4,5-triamido-6-cyclohexyloxypyrimidine hydrochloride. The preparation method comprises the following steps: enabling a sodium-containing inorganic base to exchange with cyclohexanol and then reacting with 2,4 diamido-6-chloropyrimidine to obtain 2,4-diamido-6-cyclohexyloxypyrimidine; directly adding sodium nitrite and acetic acid to obtain 2,4-diamido-5-nitroso-6-cyclohexyloxypyrimidine; hydrogenating with an organic solvent and palladium on carbon, reducing a nitroso group to obtain 2,4,5-triamido-6-cyclohexyloxypyrimidine and successively adding ethyl acetate and/or a hydrogen chloride solution to obtain the 2,4,5-triamido-6-cyclohexyloxypyrimidine hydrochloride. The preparation method disclosed by the invention has the benefits that conditions are mild, the preparation is coherent, intermediates and products in all the steps do not need to be treated and are directly added into a next step, the operation is simple, the yield is high, and raw materials are cheap and easy to obtain; the suitability for enlarged production is realized.

A convenient synthesis of optically active biopterin

Naturally occurring L-erythro-biopterin is synthesized using regioselective pteridine-ring formation from the chiral α,(β-epoxyaldehyde intermediate which is prepaccred from ethyl L-lactate via Sharpless epoxidation.