1104642-54-7Relevant academic research and scientific papers
6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis
Kempen, Isabelle,Hemmer, Marc,Counerotte, Stephane,Pochet, Lionel,de Tullio, Pascal,Foidart, Jean-Michel,Blacher, Silvia,Noel, Agnes,Frankenne, Francis,Pirotte, Bernard
experimental part, p. 2735 - 2750 (2009/04/06)
Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents.
