1104643-30-2

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (6-chloropyridin-2-yl)acetate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, tert-butyl (6-chloropyridin-2-yl)acetate is utilized as a building block for the creation of pesticides and other agrochemicals, leveraging its structural properties to enhance the effectiveness and selectivity of these compounds in agricultural applications.
Used in Materials Science:
Tert-butyl (6-chloropyridin-2-yl)acetate is employed in materials science as a component in the development of new materials with specific properties, such as those with tailored electronic, optical, or mechanical characteristics, by virtue of its chemical structure and reactivity.
Overall, the versatility of tert-butyl (6-chloropyridin-2-yl)acetate stems from its structural attributes and its role as a synthetic intermediate, making it valuable across different industries for the innovation of new products and technologies.

Upstream product

• 18368-63-3 6-chloro-2-picoline 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Rhodium(II)-Catalyzed Formal [4+1]-Cycloaddition of Pyridotriazoles and Propargyl Alcohols: Synthesis of 2,5-Dihydrofurans

A rhodium-catalyzed formal [4+1]-cycloaddition of pyridotriazoles and aryl propargyl alcohols is reported, providing an effective access to 2-pyridyl-substituted 2,5-dihydrofuran derivatives in moderate to high yields. Mechanistically, the proposed oxonium ylide intermediate in this catalytic alkyne carbocyclization transformation is verified by an interception experiment for the first time. (Figure presented.).

3 Rhodium(II)-catalyzed formal [4+1]-cycloaddition of 4 pyridotriazoles and propargyl alcohols: Synthesis of 2,5-5 6 dihydrofurans 7

A rhodium-catalyzed formal [4+1]-cy-cloaddition of pyridotriazoles and aryl propargyl alcohols is reported, providing an effective access to 2-pyridyl-substituted 2,5-dihydrofuran derivatives in moderate to high yields. Mechanistically, the proposed oxonium ylide intermediate in this catalytic alkyne carbocyclization transformation is verified by an interception experiment for the first time.

Di-tert-butyl dicarbonate: a versatile carboxylating reagent

Carbon nucleophiles generated by a non-nucleophilic base (LDA) were effectively trapped with di-tert-butyl dicarbonate (Boc-anhydride) to provide the corresponding tert-butyl aryl acetates, di-tert-butyl aryl malonates, unsymmetrical aryl malonates and te