110466-11-0Relevant academic research and scientific papers
Synthesis of Methyl-Protected (±)-Chlorizidine A
Mahajan, Jyoti P.,Mhaske, Santosh B.
, p. 2774 - 2776 (2017)
The first total synthesis of the methyl-protected (±)-chlorizidine A has been achieved in 10 steps. Pd-catalyzed decarboxylative coupling and late-stage oxidation were utilized to construct the 5H-pyrrolo[2,1-a]isoindol-5-one scaffold. Samarium(II) iodide mediated Reformatsky reaction and intramolecular Mitsunobu reactions were efficiently applied for the synthesis of the 2,3-dihydropyrrolizine ring system. Chlorizidine A is highly prone to degradation; hence, methyl-protected (±)-chlorizidine A was prepared.
Efficient construction of novel α-keto spiro ketal and the total synthesis of (±)-terreinol
Wei, Wan-Guo,Zhang, Yong-Xia,Yao, Zhu-Jun
, p. 11882 - 11886 (2007/10/03)
The first total synthesis of (±)-terreinol is described. An intramolecular Pd(II)-catalyzed cycloisomerization of a 2-(1′-alkynyl) benzyl alcohol via an apparent 6-endo diagonal pathway led to the 1H-isochromene ring system, which was further converted to
Naturally Occuring Dibenzofurans. Part 9. A Convenient Synthesis of Phthalides: The Synthesis of Methyl Di-O-methylporphyrilate
Sargent, Melvyn V.
, p. 231 - 236 (2007/10/02)
A convenient synthesis of phthalides from o-halogenobenzyl alcohols is described.This method is then applied to the synthesis of methyl di-O-methylporphyrilate (methyl 1,3-dihydro-4,10-dimethoxy-8-methyl-3-oxoisobenzofuro
