685895-46-9

Upstream product

• 5673-07-4 2,6-dimethoxytoluene 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 873310-47-5 (5-amino-2,4-dimethoxy-3-methylphenyl)methanol 
• 685895-58-3 3-heptyl-7-(2-iodo-phenyl)-7-methyl-isochromene-6,8-dione 
• 685895-63-0 cyclohexanecarboxylic acid [3-(2-formyl-3,5-dihydroxy-4-methyl-phenyl)-prop-2-ynyl]-amide 
• 685895-68-5 2-benzyl-3-heptyl-7-hydroxy-7-methyl-2H-isoquinoline-6,8-dione 
• 859507-78-1 2,4-dihydroxy-3-methyl-6-non-1-ynyl-benzaldehyde 
• 685895-47-0 acetic acid acetoxy-(3-amino-2-bromo-4,6-dimethoxy-5-methyl-phenyl)-methyl ester 
• 685895-62-9 2,4-dihydroxy-6-(3-methoxyprop-1-yn-1-yl)-3-methylbenzaldehyde 
• 685895-45-8 2-bromo-4,6-dihydroxy-5-methylbenzaldehyde 
• 685895-48-1 6-bromo-2,4-dimethoxy-3-methylbenzaldehyde 
• 110466-11-0 (6-bromo-2,4-dimethoxy-3-methylphenyl)methanol 
• 873310-51-1 acetic acid 5-[3,5-bis(tert-butyldimethylsilanyloxy)-2-hydroxymethyl-4-methylphenyl]pent-4-ynyl ester 
• 873310-50-0 acetic acid 5-[3,5-bis(tert-butyldimethylsilanyloxy)-2-formyl-4-methylphenyl]pent-4-ynyl ester 
• 873310-49-7 acetic acid 5-(2-formyl-3,5-dihydroxy-4-methylphenyl)pent-4-ynyl ester 
• 873310-48-6 (3-amino-2-bromo-4,6-dimethoxy-5-methylphenyl)methanol 

Relevant academic research and scientific papers

Efficient construction of novel α-keto spiro ketal and the total synthesis of (±)-terreinol

The first total synthesis of (±)-terreinol is described. An intramolecular Pd(II)-catalyzed cycloisomerization of a 2-(1′-alkynyl) benzyl alcohol via an apparent 6-endo diagonal pathway led to the 1H-isochromene ring system, which was further converted to

Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes

Right to the core: Gold(III)-catalyzed cycloisomerization of o-alkynylbenzaldehydes to 2-benzopyrylium salts and subsequent in situ oxidation have been employed to prepare the core structure of azaphilone natural products, such as the sphingosine kinase inhibitor S-15183 (see scheme, DCE = 1,2-dichloroethane, TFA = trifluoroacetic acid)), and several unnatural azaphilones.