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diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

110470-34-3

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110470-34-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 110470-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,4,7 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 110470-34:
(8*1)+(7*1)+(6*0)+(5*4)+(4*7)+(3*0)+(2*3)+(1*4)=73
73 % 10 = 3
So 110470-34-3 is a valid CAS Registry Number.

110470-34-3Relevant articles and documents

One-pot synthesis of α-aminophosphonates on silica under solvent-free conditions from aromatic aldehydes

Wu, Ming Shu,Zhang, Xiang Zhu

, p. 562 - 563 (2008)

α-Aminophosphonates were synthesised under solvent-free conditions on an acidic silica gel support using aromatic aldehydes, diethyl phosphite and anhydrous ammonium acetate as starting materials in moderate yields.

Substrate related O,O-dialkyldipeptidylaminophosphonates, a new type of thrombin inhibitor

Green, Donovan,Patel, Geeta,Elgendy, Said,Baban, Jehan A.,Skordalakes, Emmanuel,Husman, Wahid,Goodwin, Christopher A.,Scully, Michael F.,Kakkar, Vijay V.,Deadman, John

, p. 533 - 536 (1996)

The facile reduction of O,O-dialkyl 1-hydroxyiminoalkanephosphonate precursors, using LiBH4/Me3SiCl in THF at ambient temperature, conveniently affords O,O-dialkyl 1-aminoalkanephosphonates in good yield and high state of purity. O,O

Microwave-assisted synthesis of 1-aminoalkyl phosphonates under solvent-free conditions

Kaboudin, Babak,Nazari, Rahman

, p. 8211 - 8213 (2001)

A simple, efficient and general method has been developed for the synthesis of 1-aminoalkyl phosphonates through a one-pot reaction of aldehydes with amines in the presence of acidic alumina under solvent-free conditions using microwave irradiation. It wa

Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway

Shang, Fan-Fan,Wang, Jing Ying,Xu, Qian,Deng, Hao,Guo, Hong-Yan,Jin, Xuejun,Li, Xiaoting,Shen, Qing-Kun,Quan, Zhe-Shan

, (2021/05/03)

Four series of hypoxia-inducible factor-1 alpha (HIF-1α) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol were designed and synthesized, and their anticancer activities were evaluated. To address the structure and activity relationship of each derivative, extensive structural changes were made. HRE luciferase reporter assay demonstrated that 12 modified compounds showed superior HIF-1α inhibitory activity. Among them, compound C6 exhibited the best features: firstly, the strongest HIF-1α inhibitory activity (IC50 = 0.05 μM, 5-fold higher than that of celastrol); secondly, lower cytotoxicity (22-fold lower, C6-16.85 μM vs celastrol-0.76 μM). Thus, the safety factor of C6 was about 112 times higher than that of celastrol. Western blot assay indicated that C6 may inhibit the expression of HIF-1α protein in cells. Additionally, C6 hindered tumor cell cloning, migration and induced cell apoptosis. It is worth mentioning that in the mouse tumor xenograft model, C6 (10 mg/kg) displayed good antitumor activity in vivo, showing a better inhibition rate (74.03%) than the reference compound 5-fluorouracil (inhibition rate, 59.58%). However, the celastrol treatment group experienced collective death after four doses of the drug. Moreover, C6 minimally affected the mouse weight, indicating that its application in vivo has little toxic effect. H&E staining experiments show that it could also exacerbate the degree of tumor cell damage. The results of water solubility experiment show that the solubility of C6 is increased by 1.36 times than that of celastrol. In conclusion, C6 is a promising antitumor agent through HIF-1α pathway.

Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease

Abás, Sònia,Rodríguez-Arévalo, Sergio,Bagán, Andrea,Gri?án-Ferré, Christian,Vasilopoulou, Foteini,Brocos-Mosquera, Iria,Muguruza, Carolina,Pérez, Belén,Molins, Elies,Luque, F. Javier,Pérez-Lozano, Pilar,De Jonghe, Steven,Daelemans, Dirk,Naesens, Lieve,Brea, José,Loza, M. Isabel,Hernández-Hernández, Elena,García-Sevilla, Jesús A.,García-Fuster, M. Julia,Radan, Milica,Djikic, Teodora,Nikolic, Katarina,Pallàs, Mercè,Callado, Luis F.,Escolano, Carmen

supporting information, p. 3610 - 3633 (2020/04/30)

Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders, are orphans from a structural point of view, and new I2-IR ligands are urgently required

Design and synthesis of C-19 isosteviol derivatives as potent and highly selective antiproliferative agents

Luan, Tian,Cao, Li-Hua,Deng, Hao,Shen, Qing-Kun,Tian, Yu-Shun,Quan, Zhe-Shan

, (2019/01/16)

Six series of novel isosteviol derivatives; modified in the C-19 position; were synthesized; and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116; BEL-7402; HepG2) and the human L02 normal cell line in vitro. M

Synthesis and Biological Evaluation of (+)-Usnic Acid Derivatives as Potential Anti- Toxoplasma gondii Agents

Guo, Hong-Yan,Jin, Chun-Mei,Jin, Chunmei,Quan, Zhe-Shan,Shen, Qing-Kun,Zhang, Hai-Ming

, (2019/09/06)

Six series of (+)-usnic acid derivatives were synthesized. The IC50 values of these compounds were determined in T. gondii infected HeLa cells (μM) and in HeLa cells (μM), and their selectivity indexes (SI) were calculated. In vitro, most of th

Diethylalkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors: synthesis accompanied by experimental and molecular modeling assessments

Alimoradi, Nahid,Ashrafi-Kooshk, Mohammad Reza,Maghsoudi, Shabnam,Khodarahmi, Reza,Shahlaei, Mohsen,Adibi, Hadi,McGeary, Ross P.

, p. 20 - 28 (2017/11/21)

Purple acid phosphatases (PAPs) are binuclear metallo-hydrolases that have been isolated from various mammals, plants, fungi and bacteria. In mammals, PAP activity is associated with bone resorption and can lead to bone metabolic disorders such as osteopo

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

Park, Jaeok,Leung, Chun Yuen,Matralis, Alexios N.,Lacbay, Cyrus M.,Tsakos, Michail,Fernandez De Troconiz, Guillermo,Berghuis, Albert M.,Tsantrizos, Youla S.

, p. 2119 - 2134 (2017/03/17)

The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP). FPP plays a crucial role in the post-translational prenylation of small GTPases that perform a plethora of cellular functions. Although hFPPS is a well-established therapeutic target for lytic bone diseases, the currently available bisphosphonate drugs exhibit poor cellular uptake and distribution into nonskeletal tissues. Recent drug discovery efforts have focused primarily on allosteric inhibition of hFPPS and the discovery of non-bisphosphonate drugs for potentially treating nonskeletal diseases. Hit-to-lead optimization of a new series of thienopyrimidine-based monosphosphonates (ThP-MPs) led to the identification of analogs with nanomolar potency in inhibiting hFPPS. Their interactions with the allosteric pocket of the enzyme were characterized by crystallography, and the results provide further insight into the pharmacophore requirements for allosteric inhibition.

Synthesis of derivatives of artesunate α-aminophosphonate and their antimicrobial activities

He, Sheng,Ouyang, Xilin,Huang, Xiaochao,Hu, Weisong,Dai, Weilong,Tian, Xiaoyan,Pan, Yingming,Huang, Shiwen,Wang, Hengshan

, p. 408 - 416 (2015/06/22)

Thirteen α-aminophosphonate derivatives with artesunate were synthesized by introducing bioactive α-aminophosphonate combination with artesunate in this work. The reaction were easily carried out at normal pressure, low temperature and without any catalys

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