1104731-83-0Relevant academic research and scientific papers
Novel N-3 substituted TSAO-T derivatives: Synthesis and anti-HIV-evaluation
Bonache, Maria-Cruz,Quesada, Ernesto,Sheen, Chih-Wei,Balzarini, Jan,Sluis-Cremer, Nicolas,Perez-Perez, Maria Jesus,Camarasa, Maria-Jose,San-Felix, Ana
, p. 351 - 367 (2008/09/20)
Novel derivatives of the anti-HIV-1 agent, TSAO-T, bearing at the N-3 position alkylating groups or photoaffinity labels were prepared and evaluated for their anti-HIV activity. All of these compounds demonstrated pronounced anti-HIV-1 activity and inhibited HIV-1 RT; however, we were unable to detect stable covalent linkages between inhibitor and enzyme. In addition, compounds with an alcohol functional group connected to the N-3 position through a cis or trans double bond have been prepared. These compounds have been useful to study how the conformational restriction of the linker affects in the interaction between the N-3 substituent and the HIV-1 RT enzyme. Copyright Taylor & Francis Group, LLC.
