110480-82-5

Basic information

• Product Name: (S)-2-AMino-2-(naphthalen-1-yl)ethanol
• Synonyms: (S)-2-AMino-2-(naphthalen-1-yl)ethanol;(2S)-2-AMINO-2-(1-NAPHTHYL)ETHANOL HCL;(2S)-2-AMINO-2-NAPHTHYLETHAN-1-OL;(S)-2-AMINO-2-(NAPHTHALEN-1-YL)ETHAN-1-OL HCL
• CAS NO: 110480-82-5
• Molecular Formula: C12H13NO
• Molecular Weight: 187.23772
• Mol File: 110480-82-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130-132 °C
• Boiling Point: 392.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: 12.46±0.10(Predicted)
• CAS DataBase Reference: (S)-2-AMino-2-(naphthalen-1-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMino-2-(naphthalen-1-yl)ethanol(110480-82-5)
• EPA Substance Registry System: (S)-2-AMino-2-(naphthalen-1-yl)ethanol(110480-82-5)

Safety Data

• Hazardous Substances Data: 110480-82-5(Hazardous Substances Data)

Usage

General Description

The chemical (S)-2-Amino-2-(naphthalen-1-yl)ethanol, also known as S-Naproxen, is an amino alcohol compound with a naphthalene group. It has a chiral center and exists in two enantiomeric forms, with the S-isomer being the biologically active form. (S)-2-AMino-2-(naphthalen-1-yl)ethanol is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential therapeutic applications, particularly in the treatment of pain and inflammation. Additionally, (S)-2-Amino-2-(naphthalen-1-yl)ethanol has been investigated for its potential as a chiral auxiliary in asymmetric synthesis.

Upstream product

• 110470-39-8 (S)-ethyl 2-amino-2-(naphthalen-1-yl)acetate 
• 1400897-75-7 (S)-ethyl 2-(4-methoxyphenylamino)-2-(naphthalen-1-yl)acetate 
• 1393524-52-1 (1S)-N-(tert-butoxycarbonyl)-1-(1-naphthyl)-2-hydroxyethylamine 
• 826-74-4 1-vinylnaphthalene 
• 90-11-9 1-Bromonaphthalene 
• 1312718-96-9 2-(tert-butyldimethylsilyloxy)-1-(naphthalen-1-yl)ethanone 
• 204851-60-5 (4S)-4-benzyl-3-[(2R)-3-hydroxy-2-(1'-naphthyl)-1-oxopropyl]-2-oxazolidinone 
• 113543-62-7 (+/-)-α-Amino-1-naphthaleneacetonitrile 
• 66-77-3 1-naphthaldehyde 
• 86-87-3 naphth-1-yl acetic acid 
• 899799-12-3 1-(3-(S)-tert-butyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2-(naphthalen-1-yl)ethanone 
• 899799-14-5 2-(S)-azido-1-(3-(S)-tert-butyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2-(naphthalen-1-yl)ethanone 
• 111820-05-4 (S)-amino(naphthalen-1-yl)acetic acid 
• 204851-70-7 (R)-3-Hydroxy-2-naphthalen-1-yl-propionic acid 

Relevant articles and documents

Naphthyl-substituted bisoxazoline and pyridylbisoxazoline-copper(I) catalysts for asymmetric allylic oxidation

The synthesis of naphthyl substituted malonyl-derived and pyridine-based bisoxazolines and their applications in the asymmetric allylic oxidation of cyclohexene with t-butyl p-nitroperbenzoate have been performed with much improved reactivity (75% yield)

A general asymmetric synthesis of phenylglycinols

Hydride reduction and deprotection of siloxymethyl sulfinimines 2 reliably furnished chiral phenylglycinols 1 or 10 in high overall yield and enantiomeric purity.

An efficient synthesis of 1-naphthylbis(oxazoline) and exploration of the scope in asymmetric catalysis

Both enantiomers of 1-naphthylglycine were obtained in 99% ee by enzymatic resolution of the corresponding racemic amino acid amide, giving access to the novel ligands (R)- and (S)-naphthylbis(oxazoline). Initial studies provided insight into the scope an