1104806-97-4

Usage

Pyrazole derivative

1H-pyrazole
The compound is derived from the 1H-pyrazole structure, which is a five-membered heterocyclic ring containing two nitrogen atoms.

Nitro group

-NO2
The compound contains a nitro group, which is a functional group consisting of an oxygen-nitrogen-oxygen (-NO2) structure.

Trifluoromethylphenylmethyl substituent

-CF3C6H4CH2
The compound has a trifluoromethylphenylmethyl group attached to it, which consists of a phenyl ring (C6H5) with a trifluoromethyl (-CF3) group and a methyl (-CH2) group.

Potential medicinal properties

Pharmaceutical drug development
The compound may have properties that make it useful in the development of pharmaceutical drugs, possibly due to its unique structure and functional groups.

Chemical synthesis and research

Reagent
The compound is used as a reagent in chemical synthesis and research, indicating its versatility and importance in creating new compounds.

Applications

Intermediate in the synthesis of bioactive molecules and pharmaceutical compounds
The compound may be used as an intermediate in the synthesis of various bioactive molecules and pharmaceutical compounds, highlighting its potential in medicinal chemistry and organic synthesis.

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 1104806-98-5 1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-amine 

Relevant academic research and scientific papers

TETRAHYDROPYRIDO[3',2':4,5]PYRROLO[1,2-a]PYRAZINE-2-CARBOXAMIDE DERIVATIVES USEFUL AS RSK INHIBITORS

Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity.

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amides, that block ATF6α signaling in response to ER stress. Ceapins sensitize cells to ER stress without impacting viability of unstressed cells. Ceapins are highly specific inhibitors of ATF6α signaling, not affecting signaling through the other branches of the UPR, or proteolytic processing of its close homolog ATF6β or SREBP (a cholesterol-regulated transcription factor), both activated by the same proteases. Ceapins are first-in-class inhibitors that can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings. The discovery of Ceapins now enables pharmacological modulation all three UPR branches either singly or in combination.

SODIUM CHANNEL INHIBITORS

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, composition