1105054-49-6Relevant articles and documents
Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency
Cheng, Wei-Chieh,Wang, Jen-Hon,Li, Huang-Yi,Lu, Sheng-Jhih,Hu, Jia-Ming,Yun, Wen-Yi,Chiu, Cheng-Hsin,Yang, Wen-Bin,Chien, Yin-Hsiu,Hwu, Wuh-Liang
, p. 14 - 20 (2016)
A unique molecular library consisting of all sixteen synthetic ADMDP (1-aminodeoxy-DMDP) stereoisomers has been prepared and evaluated for inhibitory activity against α-Gal A, and ability to impart thermal stabilization of this enzyme. The results of this
Small structure tree alkali compound and its preparation method and application
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Paragraph 0138; 0141; 0146; 0147; 0148, (2018/04/26)
The invention relates to a Broussonetia kazinoki alkaline compound. Structure of the compound is shown as a formula (1). The invention further provides a preparation method of the compound, a glycosidase inhibitor by using the compound or the compound prepared by the method as an active ingredient and application of the compound or the compound, prepared by the method, serving as an active ingredient in preparing drug. The Broussonetia kazinoki alkaline compound has high glycosidase inhibiting activity and potential medicinal value.
TREATMENT OF FABRY DISEASE
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Paragraph 0105; 0107; 0108; 0141; 0142, (2018/04/11)
Disclosed herein are novel uses of a polyhydroxylated pyrrolidine for the manufacture of a medicament for treating Fabry disease (FD). Accordingly, the present disclosure provides a method of treating a subject having or suspected of having FD. The method