1105062-49-4

Upstream product

• 2646-91-5 2,3-difluorobenzaldehyde 

Downstream Products

• 1105062-48-3 2-(2,3-Difluoro-phenyl)-5H-imidazo[4,5-d]pyridazin-4-ylamine 
• 1105062-59-6 2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine-4,7-diamine 
• 1105058-57-8 2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 1186484-99-0 5-(4-bromobenzyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 1174506-55-8 5-((2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)-3-(2-methoxypyrimidin-5-yl)isoxazole 
• 1186483-87-3 5-(3-(2,4-bis(trifluoromethyl)phenyl)propyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 1186483-60-2 5-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 1186483-13-5 5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 1186484-12-7 2-(2,3-difluorophenyl)-5-((5-(4-propoxy-2-(trifluoromethyl)phenyl)pyrazin-2-yl)methyl)-5H-imidazo[4,5-d]pyridazine 
• 1186483-83-9 2-(2,3-difluorophenyl)-5-((5-(4-propoxy-2-(trifluoromethyl)phenyl)pyrimidin-2-yl)methyl)-5H-imidazo[4,5-d]pyridazine 
• 1186482-08-5 5-((6-chloropyridazin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 

Relevant academic research and scientific papers

Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism

By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this e

Processes For The Preparation Of Anti-Viral Compounds And Compositions Containing Them

Disclosed are processes for the preparation of compounds of formula I and compositions that comprise said compounds of formula I. Also disclosed are processes for the preparation of compounds of formula III and compositions that comprise said compounds of formula III.

ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.

ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses. (I)