110514-05-1Relevant academic research and scientific papers
Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity
Kadayat, Tara Man,Park, Chanmi,Jun, Kyu-Yeon,Magar, Til Bahadur Thapa,Bist, Ganesh,Yoo, Han Young,Kwon, Youngjoo,Lee, Eung-Seok
, p. 160 - 173 (2015)
For the development of potential anticancer agents, we designed and synthesized 30 new 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives containing aryl moiety such as furyl, thienyl, pyridyl, and phenyl at 2- and 4-position of 5H-indeno[1,2-b]pyridine. The
Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors
Park, Seojeong,Kadayat, Tara Man,Jun, Kyu-Yeon,Thapa Magar, Til Bahadur,Bist, Ganesh,Shrestha, Aarajana,Lee, Eung-Seok,Kwon, Youngjoo
, p. 14 - 28 (2017)
On the basis of previous reports on the importance of thienyl, furyl or phenol group substitution on 5H-indeno[1,2-b]pyridine skeleton, a new series of rigid 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine derivatives were systematically designed and
Co(II) and Mn(II) coordination polymers: Ligand functional and positional isomeric effects, structural diversities, luminescence sensing and magnetic properties
Yan, Qing-Qing,Li, Bin,Yong, Guo-Ping
, (2021)
Two new isostructural 3D Co(II) and Mn(II) coordination polymers (CPs) [M(L1′)2] (M = Co(1) and Mn (2)) were prepared by reactions of metal salts and 2-connected 4-(4-(3-cyanophenyl)-[2,3′-bipyridin]-6-yl)benzoic acid ligand (HL1′). Interestingly, when simple modification of the ligand functional group (from the cyano to carboxylate group), other two new 3D Co(II) [Co(HL2′)2] (3) and Mn(II) [Mn(L2′)(H2O)] (4) CPs are constructed by using 3-connected 3-(6-(4-carboxyphenyl)-[2,3′-bipyridin]-4-yl) benzoic acid (H2L2′), which are ascribed to the change in ligand functionality (from the cyano to carboxylate group). Moreover, the variable positions of cyano group (or carboxylate group) at the ligand isomers also can tune structural diversities. Present and previous works indicate that the isomeric effects of the ligand isomers play important role in adjusting structures of the Co(II) CPs. 1–4 were fully characterized by IR, elemental analyses, TGA, PXRD, and single-crystal X-ray diffraction. Interestingly, 2 and 4 can serve as sensing materials for detecting Fe3+ and Cr2O72? ions. Furthermore, the magnetic properties of four CPs have been investigated. The present work provides a promising approach to design and construct CPs or MOFs by adjusting ligand functionality and positional isomeric effects.
Crystal structures and properties of four coordination polymers based on a new asymmetric ligand: Tuning structure/dimensionality by various organic solvents
Li, Bin,Yan, Qing-Qing,Yong, Guo-Ping
, (2020/02/05)
An asymmetric ligand, 4,4′-([2,3′-bipyridine]-4,6-diyl)dibenzoic acid (H2L) was successfully used to construct four new coordination polymers, namely [M(HL)2]n (M = Cd(1), Co(2), Zn(3)) and [Ni(L)(H2O)2/su
Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison
Karki, Radha,Park, Chanmi,Jun, Kyu-Yeon,Kadayat, Tara Man,Lee, Eung-Seok,Kwon, Youngjoo
, p. 360 - 378 (2015/03/18)
Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups
Synthesis and biological activity of 2,4-di- p -phenolyl-6- 2 -furanyl-pyridine as a potent topoisomerase II poison
Karki, Radha,Park, Chanmi,Jun, Kyu-Yeon,Kadayat, Tara Man,Lee, Eung-Seok,Kwon, Youngjoo
, p. 360 - 378 (2015/02/19)
Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups
2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6- dihydrothieno[2,3-h] quinoline derivatives for topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study
Thapa, Pritam,Karki, Radha,Yoo, Han Young,Park, Pil-Hoon,Lee, Eunyoung,Jeon, Kyung-Hwa,Na, Younghwa,Cho, Won-Jea,Kwon, Youngjoo,Lee, Eung-Seok
experimental part, p. 67 - 78 (2012/04/10)
Designed and synthesized thirty-two 2,4-diaryl-5,6-dihydro-1,10- phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives as rigid analogs of 2,4,6-trisubstituted pyridines were evaluated for topoisomerase I and II inhibitory activitie
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
Thapa, Pritam,Karki, Radha,Yun, Minho,Kadayat, Tara Man,Lee, Eunyoung,Kwon, Han Byeol,Na, Younghwa,Cho, Won-Jea,Kim, Nam Doo,Jeong, Byeong-Seon,Kwon, Youngjoo,Lee, Eung-Seok
experimental part, p. 123 - 136 (2012/07/27)
We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisom
