110524-94-2Relevant academic research and scientific papers
Catalytic asymmetric staudinger reactions to form β-lactams: An unanticipated dependence of diastereoselectivity on the choice of the nitrogen substituent
Lee, Elaine C.,Hodous, Brian L.,Bergin, Enda,Shih, Crystal,Fu, Gregory C.
, p. 11586 - 11587 (2005)
There are relatively few methods for the catalytic asymmetric synthesis of β-lactams, and those that have been reported are generally cis selective. This communication describes the first catalytic enantioselective Staudinger reactions that preferentially furnish trans β-lactams (trans = relationship of Ph to R1). The key to this method is the use of an N-triflyl protecting group for the imine. Along with serving as interesting targets in their own right, N-triflyl β-lactams readily react with nucleophiles to generate useful families of compounds, such as γ-amino alcohols and β-amino acids. Copyright
A NEW PRINCIPLE FOR THE CONSTRUCTION OF SUPERSTRONG ELECTRON-WITHDRAWING SUBSTITUENTS
Yagupol'skii, L. M.,Popov, V. I.,Pavlenko, N. V.,Maletina, I. I.,Mironova, A. A.,et al.
, p. 1947 - 1950 (2007/10/02)
Derivatives of benzene containing the CH=NSO2CF3, (C3F7)2P=NSO2CF3, I=NSO3CF3, and I(=NSO2CF3)2 groups were synthetized.The ?I and ?R constants were determined by 19F NMR spectroscopy of the corresponding substituted fluorobenzenes.I
