110539-10-1

Basic information

• Product Name: 1,2-Cyclohexanediol, dinitrate
• CAS NO: 110539-10-1
• Molecular Formula: C6H10N2O6
• Molecular Weight: 206.155
• Mol File: 110539-10-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-Cyclohexanediol, dinitrate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediol, dinitrate(110539-10-1)
• EPA Substance Registry System: 1,2-Cyclohexanediol, dinitrate(110539-10-1)

Safety Data

• Hazardous Substances Data: 110539-10-1(Hazardous Substances Data)

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 110-83-8 cyclohexene 
• 931-17-9 1,2-Cyclohexanediol 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 1460-57-7 trans-1,2-cyclohexandiol 
• 5515-64-0 trans-1,3-cyclohexanediol 

Relevant articles and documents

Nitration by oxides of nitrogen, part 4: Unexpected behaviour of certain aziridines and azetidines upon reaction with dinitrogen pentoxide

Seven aziridines and azetidines, either unsubstituted on ring nitrogen or bearing N-acyl (N,N-dimethylcarbamyl or propionyl) groups, were reacted with N2O5 in halogenated solvents with the following results:- the behaviour of the aziridines was highly dependent on the N-substituent, giving respectively dinitrate esters, nitramine-nitrate or predominantly uncharacterisable products, whereas the azetidines gave in all cases N-nitroazetidine. The different behaviour is believed to result from ring strain effects.

Preparation of Di- and polynitrates by ring-opening nitration of epoxides by dinitrogen pentoxide (N2O5)

Eighteen epoxides of various kinds were reacted with N2O5 in chlorinated hydrocarbon solvents (principally CH2Cl2) to give vicinal nitrate ester products by a novel ring-opening nitration reaction. The procedure offers easier temperature control and simpler isolation procedures compared with conventional mixed acid nitrations; it also enables selective nitration reactions to be carried out on polyfunctional substrates. The scope and limitations of the reaction, as well as those of an alternative route utilising N2O4 with in situ oxidation of an intermediate nitrite-nitrate, are discussed.

Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance

The invention relates to pharmaceutical compositions containing novel nitrate esters, of which it was found that they are useful for the treatment of ischemiatic heart diseases, decompensatio cordis, myocardial infarction and hypertension.